Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
| Autor: | Richard Vollenberg, Eva Lorentzen, Joachim E. Kühn, Tobias Brix, Phil-Robin Tepasse, Martin Dugas, Hartmut Schmidt, Tanja Grote-Westrick |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Short Communication 030106 microbiology Disease Infectious and parasitic diseases RC109-216 Antibodies Viral Severity of Illness Index Coronavirus OC43 Human 03 medical and health sciences Betacoronavirus 0302 clinical medicine Internal medicine Intensive care seasonal coronaviruses Outpatient setting medicine Humans 030212 general & internal medicine Aged Retrospective Studies Aged 80 and over biology business.industry SARS-CoV-2 Small children Clinical course COVID-19 General Medicine OC43 Middle Aged Infectious Diseases biology.protein Biomarker (medicine) Observational study Female Seasons Antibody HKU1 business Severe course Coronavirus Infections Biomarkers |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 105, Iss, Pp 304-306 (2021) |
| ISSN: | 1878-3511 1201-9712 |
| Popis: | The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. Recently, an association between contact to small children and mild course of COVID-19 was reported. We performed an observational study to assess the impact of previous infections with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included (age 30 - 82 years; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease and 25 outpatients (age and gender matched to inpatients). Patients with critical disease had significantly lower levels of HCoV OC43- (p=0.016) and HCoV HKU1-specific (p=0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that previous infections with seasonal coronaviruses might protect against a severe course of disease. This finding should be validated in other settings and could contribute to identify persons at risk before an infection. |
| Databáze: | OpenAIRE |
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