Health related quality of life associated with extreme obesity in adolescents - results from the baseline evaluation of the YES-study

Autor: Thomas Reinehr, Esther Bollow, André Scherag, Wieland Kiess, J. von Schnurbein, S. Brandt, Johannes Hebebrand, Christina M. Teuner, Reinhard W. Holl, Julia Felix, Renee Stark, Anja Moss, Reiner Leidl, Yvonne Mühlig, Belinda Lennerz, Susanna Wiegand, Rolf Holle, Martin Wabitsch, Elena Sergeyev
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Quality of life
Pediatric Obesity
Adolescent
Ogg
Medizin
030209 endocrinology & metabolism
Adolescents
lcsh:Computer applications to medicine. Medical informatics
Quality Of Life
Extreme Obesity
Obesity Grades
Eq-5d-3l
Disabkids
Kindlr
Bmi
BMI
03 medical and health sciences
Screen time
0302 clinical medicine
Obesity grades
Surveys and Questionnaires
medicine
KINDLR
Humans
Prospective Studies
030212 general & internal medicine
Sex Distribution
Young adult
Socioeconomic status
business.industry
Research
Public Health
Environmental and Occupational Health
Regression analysis
General Medicine
computer.file_format
medicine.disease
Obesity
Extreme obesity
humanities
Obesity
Morbid
Socioeconomic Factors
EQ-5D-3 L
Regression Analysis
lcsh:R858-859.7
Female
business
computer
Demography
Cohort study
DISABKIDS
Zdroj: Health Qual. Life Outcomes 18:58 (2020)
Health and Quality of Life Outcomes, Vol 18, Iss 1, Pp 1-11 (2020)
Health and Quality of Life Outcomes
Popis: Background Obesity can significantly reduce health-related quality of life (HRQoL) and may lead to numerous health problems even in youths. This study aimed to investigate whether HRQoL varies among youths with obesity depending on grade of obesity and other factors. Methods For the Youths with Extreme obesity Study (YES) (2012–2014), a prospective multicenter cohort study, a baseline sample of 431 obese and extremely obese adolescents and young adults (age 14 to 24 years, BMI ≥30 kg/m2) was recruited at four German university medical centers and one job center. Obesity grade groups (OGG) were defined according to BMI (OGG I: 30–34.9 kg/m2, OGG II: 35–39.9 kg/m2, OGG III (extreme obesity): ≥40 kg/m2). HRQoL was measured with the Euroqol-5D-3 L (EQ-5D-3 L), DISABKIDS chronic generic (DCGM-31) and the KINDLR obesity module. Differences between OGGs were assessed with logistic and linear regression models, adjusting for age, sex, and study center in the base model. In a second regression analysis, we included other characteristics to identify possible determinants of HRQoL. Results Three hundred fifty-two adolescents (mean age: 16.6 (±2.4), mean BMI: 39.1 (±7.5) kg/ m2) with available HRQoL data were analysed. HRQoL of youths in all OGGs was markedly lower than reference values of non-obese adolescents. Adjusting for age and sex, HRQoL of youths in OGG III significantly impaired compared to OGG I. Youths in OGG III were 2.15 times more likely to report problems with mobility in the EQ-5D-3 L than youths in OGG I. A mean difference of 9.7 and 6.6 points between OGG III and I were found for DCGM-31 and KINDL respectively and 5.1 points between OGG II and I for DCGM-31. Including further variables into the regression models, showed that HRQoL measured by DCGM-31 was significantly different between OGGs. Otherwise, female sex and having more than 4 h of daily screen time were also associated with lower HRQoL measured by DCGM-31 and KINDL. Conclusion HRQoL of adolescents with obesity is reduced, but HRQoL of adolescents with extreme obesity is particularly affected. Larger and longitudinal studies are necessary to understand the relation of extreme obesity and HRQoL, and the impact of other lifestyle or socioeconomic factors. Trial Registration Clinicaltrials.gov NCT01625325; German Clinical Trials Register (DRKS) DRKS00004172.
Databáze: OpenAIRE
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