Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats

Autor: Wan Teng Lin, Catherine Reena Paul, Chih Yang Huang, Wen-Dee Chiang, Zong Yan Lee
Přispěvatelé: Ministry of Science and Technology, Taiwan
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Food & Nutrition Research, Vol 60, Iss 0, Pp 1-8 (2016)
Food & Nutrition Research; Vol 60 (2016)
Food & Nutrition Research
ISSN: 1654-661X
1654-6628
Popis: Background : Non-alcoholic fatty liver disease (NAFLD) is one of the most common outcomes of obesity and is characterized by the accumulation of triglycerides, increased tissue apoptosis, and fibrosis. NAFLD is more common among elderly than in younger age groups, and it causes serious hepatic complications. Objective : In this study, alcalase treatment derived potato protein hydrolysate (APPH) with lipolysis-stimulating property has been evaluated for its efficiency to provide hepato-protection in a high-fat-diet (HFD)-fed aging rats. Design : Twenty-four-month-old SD rats were randomly divided into six groups ( n =8): aged rats fed with standard chow, HFD-induced aged obese rats, HFD with low-dose (15 mg/kg/day) APPH treatment, HFD with moderate (45 mg/kg/day) APPH treatment, HFD with high (75 mg/kg/day) APPH treatment, and HFD with probucol. Results : APPH was found to reduce the NAFLD-related effects in rat livers induced by HFD and all of the HFD-fed rats exhibited heavier body weight than those with control chow diet. However, the HFD-induced hepatic fat accumulation was effectively attenuated in rats administered with low (15 mg/kg/day), moderate (45 mg/kg/day), and high (75 mg/kg/day) doses of APPH. APPH oral administration also suppressed the hepatic apoptosis- and fibrosis-related proteins induced by HFD. Conclusions : Our results thus indicate that APPH potentially attenuates hepatic lipid accumulation and anti-apoptosis and fibrosis effects in HFD-induced rats. APPH may have therapeutic potential in the amelioration of NAFLD liver damage. Keywords: apoptosis; fibrosis; high fat diet; lipolysis stimulating protein hydrolysates; obesity; APPH (Published: 12 July 2016) Citation: Food & Nutrition Research 2016, 60: 31417 - http://dx.doi.org/10.3402/fnr.v60.31417
Databáze: OpenAIRE
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