Narrowband ultraviolet B phototherapy does not influence serum and red cell folate levels in patients with psoriasis
| Autor: | David Turner, V. Goulden, Rebecca J Batchelor, Rebecca F. Rose |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Dermatology Risk Assessment Severity of Illness Index Gastroenterology Narrowband ultraviolet B phototherapy Cohort Studies Young Adult Folic Acid Internal medicine Psoriasis medicine Humans In patient Risk factor Aged Probability Pregnancy business.industry Middle Aged medicine.disease Red blood cell Treatment Outcome medicine.anatomical_structure Red Cell Folate Female Ultraviolet Therapy business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of the American Academy of Dermatology. 61:259-262 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2009.03.011 |
| Popis: | Background Narrowband ultraviolet (UV) B phototherapy (nbUVB) is a widely used modality in the treatment of psoriasis and is generally accepted to be safe in pregnancy. Previous studies have described photodegradation of serum folate after exposure to UVA radiation but the effect of UVB is not known. Insufficient folate levels predispose to neural tube defects in pregnancy. In addition, folate deficiency may increase the risk of colorectal carcinoma and influence serum homocysteine levels, which are thought to be a risk factor for cardiovascular disease. Objective We sought to determine whether exposure to nbUVB reduces folate levels. Methods This single-center, open observational study was conducted in a teaching hospital setting. Serum and red cell folate levels were measured in patients with psoriasis attending for nbUVB at baseline and after a minimum of 18 exposures. Results A total of 35 patients completed the study. Mean serum and red cell folate levels at baseline were 6.34 and 410 ng/ml, respectively. After nbUVB, mean serum and red cell folate levels were 6.35 and 423 ng/ml, respectively. This was not significantly different from baseline measurements ( P = .99 serum folate and P = .57 red cell folate). Limitations This study examined the effect of a standard course of 18 exposures of nbUVB on folate levels, rather than prolonged treatment. Adult patients with psoriasis only were investigated. Conclusion A standard course of nbUVB does not have an effect on serum and red cell folate levels in patients with psoriasis. |
| Databáze: | OpenAIRE |
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