Intrafusal effects of botulinum toxin in post-stroke upper limb spasticity
| Autor: | Carlo Trompetto, Alfredo Berardelli, G. Francavilla, Marco Bove, Laura Avanzino, Giovanni Abbruzzese |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Reflex Stretch medicine.medical_specialty botulinum toxin intrafusal fibres spasticity tonic vibration reflex Wrist Injections Intramuscular Upper Extremity medicine Humans Spasticity Tonic vibration reflex Botulinum Toxins Type A Aged Analysis of Variance business.industry Electromyography Focal dystonia Middle Aged medicine.disease Botulinum toxin Surgery Stroke medicine.anatomical_structure Neurology Neuromuscular Agents Muscle Spasticity Anesthesia Reflex Post stroke Female Neurology (clinical) Upper limb spasticity medicine.symptom business medicine.drug Muscle Contraction |
| Popis: | A previous study in subjects with focal dystonia suggested that the greater and longer-lasting effect induced by botulinum toxin type A (BoNT-A) on the tonic vibration reflex (TVR) than on the maximal M-wave (M-max) might be the physiological marker of the toxin's action at the level of intrafusal muscle fibres. With this approach, we investigated the possible effect of BoNT-A on fusimotor synapses in eight patients with post-stroke spasticity (four with no residual motor capacity before treatment and four with partially spared muscle strength and residual motor capacity). TVR and M-max were recorded from the wrist and finger flexor muscles before treatment and at 1, 4 and 7 months afterwards. The TVR reduction was greater than the M-max reduction and remained fairly constant over time only in the subjects with a residual motor capacity before the treatment. This pilot study suggests that some degree of strength and active movement is necessary for the action of BoNT-A on intrafusal fibres. |
| Databáze: | OpenAIRE |
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