Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Autor: | David E. Greenberg, Amanda Jezek, Kevin Outterson, Amila K. Nanayakkara, Vance G. Fowler, Helen W. Boucher |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
medicine.drug_class Antibiotics Opportunistic Infections medicine.disease_cause Antimicrobial Stewardship Immunocompromised Host Antibiotic resistance Drug Resistance Multiple Bacterial Neoplasms medicine Humans Intensive care medicine Prescription Drug Misuse Cause of death biology Pseudomonas aeruginosa business.industry Cancer Hematology medicine.disease biology.organism_classification Anti-Bacterial Agents Acinetobacter baumannii Oncology Etiology business Enterococcus faecium |
Zdroj: | CA: A Cancer Journal for Clinicians. 71:488-504 |
ISSN: | 1542-4863 0007-9235 |
Popis: | Infection is the second leading cause of death in patients with cancer. Loss of efficacy in antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing success of cancer therapy. In this review, the authors focus on recent updates on the impact of antibiotic resistance in the cancer setting, particularly on the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.). This review highlights the health and financial impact of antibiotic resistance in patients with cancer. Furthermore, the authors recommend measures to control the emergence of antibiotic resistance, highlighting the risk factors associated with cancer care. A lack of data in the etiology of infections, specifically in oncology patients in United States, is identified as a concern, and the authors advocate for a centralized and specialized surveillance system for patients with cancer to predict and prevent the emergence of antibiotic resistance. Finding better ways to predict, prevent, and treat antibiotic-resistant infections will have a major positive impact on the care of those with cancer. |
Databáze: | OpenAIRE |
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