Pathways of T cell activation and terminal differentiation in chronic inflammation
| Autor: | Andrew P. Cope, Pia Isomäki, M Panesar, Joanna M. Clark |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_treatment
T cell T-Lymphocytes Immunology Inflammation Lymphocyte Activation Arthritis Rheumatoid Immune system medicine Immunology and Allergy Animals Humans Receptor Pharmacology Chemistry Effector Tumor Necrosis Factor-alpha T-cell receptor Cell Differentiation medicine.disease Cytokine medicine.anatomical_structure Phenotype Rheumatoid arthritis Chronic Disease Cytokines medicine.symptom Signal Transduction |
| Zdroj: | Current drug targets. Inflammation and allergy. 4(3) |
| ISSN: | 1568-010X |
| Popis: | Immune and inflammatory responses are governed by antigen-specific T cells, whose activation, differentiation and effector function are induced by signals delivered via the T cell antigen receptor (TCR) and by costimulatory and cytokine receptors. The molecular events leading to the activation of naive T cells have been extensively studied and are well characterized. Much less is known about the molecular and biochemical events regulating the activation of T cells in chronic inflammatory diseases such as rheumatoid arthritis (RA). This review examines the current state of knowledge of T cell activation in chronic inflammation, focusing on RA, and summarizes experimental data which indicate that the chronic inflammatory process may profoundly affect TCR and cytokine signal transduction pathways. We present evidence suggesting that in chronic inflammation, the antigen-driven TCR-mediated processes are attenuated, while cytokine-driven effector responses are sustained or even enhanced. The possible implications of this inbalance are discussed. |
| Databáze: | OpenAIRE |
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