FGF21 Is a Hormonal Mediator of the Human 'Thrifty' Metabolic Phenotype
| Autor: | Mary Walter, Jonathan Krakoff, Karyne Lima Vinales, Clifton Bogardus, Brittany Begaye, Paolo Piaggi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty FGF21 Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Carbohydrate metabolism Biology Diet High-Fat Weight Gain Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Diet Protein-Restricted Internal Medicine medicine Humans Body Weight Weight change Metabolism Middle Aged Carbohydrate Fibroblast Growth Factors Glucose Phenotype 030104 developmental biology Endocrinology Female Blood sugar regulation medicine.symptom Energy Metabolism Weight gain Obesity Studies Biomarkers Hormone |
| Zdroj: | Diabetes |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | Fibroblast growth factor 21 (FGF21) regulates energy expenditure (EE) and influences weight change during low-protein overfeeding in rodent models. The change in EE after a low-protein overfeeding diet is a predictor of weight change in humans and a feature of the “thrifty” metabolic phenotype. However, there are no studies showing an association between circulating FGF21 and diet-related EE in humans. We assessed the changes in plasma FGF21 concentrations after 24 h of seven dietary interventions with different macronutrient content while in a whole-room indirect calorimeter in 64 healthy subjects with normal glucose regulation. Plasma FGF21 concentration consistently increased by threefold only after the two low-protein (3%) overfeeding diets, one high in carbohydrate (75%) and the other high in fat (46%), with larger increases in FGF21 being associated with greater increases in 24-h EE. Subjects with smaller increases in FGF21 after the low-protein high-fat diet gained more weight after 6 months in free-living conditions. Therefore, the individual predisposition to weight gain over time can be assessed by 24-h overfeeding a low-protein diet and measurements of plasma FGF21 concentrations. Individuals with a blunted FGF21 response to a low-protein diet have a thrifty metabolism and are at risk for future weight gain. |
| Databáze: | OpenAIRE |
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