Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles

Autor: Nima Dehghani, Sydney S. Cash, Andrea O. Rossetti, Eric Halgren, Chih Chuan Chen
Přispěvatelé: Unité de Neurosciences Information et Complexité [Gif sur Yvette] (UNIC), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Department Neurology, Department of Neurosurgery, MGH, Harvard University [Cambridge], Service de Neurologie, Centre Universitaire Hospitalier Vaudois, Department of Neurology, National Taiwan University Hospital, Multimodal Imaging Laboratory, Department Radiology and Neurosciences (UCSD), University of California [San Diego] (UC San Diego), University of California-University of California
Rok vydání: 2010
Předmět:
Adult
Male
MESH: Magnetoencephalography
Physiology
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Thalamus
Sleep spindle
Electroencephalography
Young Adult
Cortex (anatomy)
MESH: Electroencephalography
medicine
Humans
MESH: Cortical Synchronization
Cortical Synchronization
MESH: Principal Component Analysis
Principal Component Analysis
Sleep Stages
MESH: Humans
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
medicine.diagnostic_test
General Neuroscience
Magnetoencephalography
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
MESH: Adult
Articles
MESH: Sleep Stages
Sleep in non-human animals
MESH: Male
medicine.anatomical_structure
nervous system
MESH: Young Adult
Data Interpretation
Statistical

Female
Psychology
MESH: Data Interpretation
Statistical

MESH: Female
Neuroscience
Zdroj: Journal of Neurophysiology
Journal of Neurophysiology, American Physiological Society, 2010, 104 (1), pp.179-188. ⟨10.1152/jn.00198.2010⟩
ISSN: 1522-1598
0022-3077
DOI: 10.1152/jn.00198.2010
Popis: International audience; Sleep spindles are approximately 1 s bursts of 10-16 Hz activity that occur during stage 2 sleep. Spindles are highly synchronous across the cortex and thalamus in animals, and across the scalp in humans, implying correspondingly widespread and synchronized cortical generators. However, prior studies have noted occasional dissociations of the magnetoencephalogram (MEG) from the EEG during spindles, although detailed studies of this phenomenon have been lacking. We systematically compared high-density MEG and EEG recordings during naturally occurring spindles in healthy humans. As expected, EEG was highly coherent across the scalp, with consistent topography across spindles. In contrast, the simultaneously recorded MEG was not synchronous, but varied strongly in amplitude and phase across locations and spindles. Overall, average coherence between pairs of EEG sensors was approximately 0.7, whereas MEG coherence was approximately 0.3 during spindles. Whereas 2 principle components explained approximately 50% of EEG spindle variance, >15 were required for MEG. Each PCA component for MEG typically involved several widely distributed locations, which were relatively coherent with each other. These results show that, in contrast to current models based on animal experiments, multiple asynchronous neural generators are active during normal human sleep spindles and are visible to MEG. It is possible that these multiple sources may overlap sufficiently in different EEG sensors to appear synchronous. Alternatively, EEG recordings may reflect diffusely distributed synchronous generators that are less visible to MEG. An intriguing possibility is that MEG preferentially records from the focal core thalamocortical system during spindles, and EEG from the distributed matrix system.
Databáze: OpenAIRE