The effect of high-fat diet and 13-cis retinoic acid application on lipid profile, glycemic response and oxidative stress in female Lewis rats

Autor: Maja Tolušić Levak, Dyana Odeh, Anđela Grgić, Martin Vargek, Nada Oršolić, Branko Dmitrović, Marija Delaš Aždajić, Edi Rođak, Marko Lovrić, Robert Mujkić, Tatjana Belovari, Ivana Ilić
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Very low-density lipoprotein
Physiology
Organic chemistry
Adipose tissue
Weight Gain
medicine.disease_cause
Biochemistry
Fats
chemistry.chemical_compound
Endocrinology
0302 clinical medicine
Medicine and Health Sciences
Medicine
Isotretinoin
Vitamin A
Adipogenesis
Multidisciplinary
medicine.diagnostic_test
Vitamins
Lipids
Physical sciences
Chemistry
Adipose Tissue
Physiological Parameters
Connective Tissue
Female
Anatomy
medicine.symptom
Research Article
Vitamin
medicine.medical_specialty
Science
030209 endocrinology & metabolism
Diet
High-Fat
Chemical compounds
03 medical and health sciences
Insulin resistance
Internal medicine
Organic compounds
Animals
Obesity
Nutrition
Endocrine Physiology
business.industry
Body Weight
Biology and Life Sciences
Lipid metabolism
Cell Biology
Lipid Metabolism
medicine.disease
Diet
Oxidative Stress
Glucose
Biological Tissue
030104 developmental biology
chemistry
Rats
Inbred Lew
adipose tissue
diet
high fat
rats
inbred Lew
Insulin Resistance
business
Lipid profile
Weight gain
Oxidative stress
Zdroj: PLoS ONE, Vol 15, Iss 9, p e0238600 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Vitamin A and its metabolites are key regulators of the development of adipose tissue and associated metabolic complications. The aim of this study was to determine the effect of high fat diet and 13-cis retinoic acid (13 cRA) application on metabolic parameters, adipogenic and inflammatory indicators in female Lewis rats. Female rats of Lewis strain were fed standard laboratory diet (STD) and high fat diet (HFD, 45% of saturated fatty acids) during 30 days. The groups were divided into additional 3 groups (6 rats each): two experimental groups that received 13 cRA orally on a daily basis during 30 days (7.5 mg/kg and 15 mg/kg, respectively) and the control group that was given sunflower oil. Animals were sacrificed after 60 days. Feeding of Lewis rats with chronic HFD diet with 13 cRA supplementation increased weight gain, adiposity index, dyslipidaemia, hyperleptinaemia, insulin resistance, VLDL concentrations, oxidative stress and atherogenic indices. Administration of 13 cRA in Lewis rats fed STD did not change the weight of the animals, but it slightly increased the atherogenic parameters. 13 cRA and HFD affect metabolic parameters, glucose and lipid metabolism in Lewis rats and its administration has a completely different effect on metabolism in rats fed STD, highlighting the complex role of vitamin A supplementation in obesity. Other factors, such as genetics, age, sex, adipose tissue distribution, also must be taken into consideration.
Databáze: OpenAIRE
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