Endourethral brachytherapy for prevention of recurrent urethral stricture following internal urethrotomy—first clinical experiences and results
| Autor: | Michael Heinrich Seegenschmiedt, Darko Kröpfl, Thomas Olschewski |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adenoma
Adult Male Cancer Research medicine.medical_specialty Urethrotomy Urethral stricture medicine.medical_treatment Brachytherapy Urinary catheterization Postoperative Complications Patient satisfaction Secondary Prevention medicine Humans Radiology Nuclear Medicine and imaging Internal urethrotomy Aged Aged 80 and over Urethral Stricture Radiation business.industry Prostatectomy Therapeutic effect Prostatic Neoplasms Middle Aged medicine.disease Surgery Oncology Urinary Catheterization business Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 57:1400-1404 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(03)00779-x |
| Popis: | Purpose To evaluate the therapeutic effect of endourethral brachytherapy for prevention of recurrent urethral stricture after internal urethrotomy. Methods and materials Endourethral high-dose-rate (HDR) brachytherapy was performed in 10 male patients with recurrent urethral strictures after radical prostatectomy or transurethral resection of prostatic adenoma. Brachytherapy commenced on the day of the actual intervention and continued over 3 days; the radiotherapy dose was 4 × 3=12 Gy for the first 3 patients and 4 × 4 Gy=16 Gy for the following 7 patients. Results During follow-up (range: 8–27 months, mean: 14.8 months), 9 of 10 patients remained relapse-free, i.e., without recurrent strictures or requiring another urethrotomy. In 1 patient with a restricture after endourethral brachytherapy, a second brachytherapy course was performed; nevertheless, he experienced a further restricture 12 months after the second intervention. No radiation-induced acute toxicity occurred, but 1 patient developed incontinence after the current urethrotomy. Overall, patient satisfaction and compliance with the therapeutic procedures was high. Conclusion Endourethral HDR brachytherapy proved to be a safe method that can reduce urethral restricture. Further follow-up is needed to prove long-term efficacy of this treatment. Further investigations are planned to evaluate the adequate fractionation and possible late treatment sequelae. |
| Databáze: | OpenAIRE |
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