HFE gene mutations in patients with acute leukemia

Autor:	Luciano Prossomariti, Leonilde Pagano, Maria Rosaria D'Amico, Assunta Viola, Felicetto Ferrara, Rossella D'Elia, Daniela Laudati, Massimiliano Ammirabile, Salvatore Palmieri
Rok vydání:	2006
Předmět:	Adult Male Acute promyelocytic leukemia Cancer Research medicine.medical_specialty Adolescent Genotype medicine.disease_cause Gastroenterology hemic and lymphatic diseases Internal medicine medicine Humans Histidine Hemochromatosis Protein Allele frequency Aged Aged 80 and over Aspartic Acid Mutation Acute leukemia Leukemia business.industry Incidence (epidemiology) Histocompatibility Antigens Class I Membrane Proteins Myeloid leukemia Hematology Odds ratio Middle Aged medicine.disease Confidence interval Oncology Acute Disease Immunology Female business
Zdroj:	Leukemia & Lymphoma. 47:2331-2334
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428190600821898
Popis:	An increased incidence of HFE gene mutations has been described in hematologic malignancies. In the present study, we investigated the allelic frequency of HFE gene mutations in 154 adult patients with acute leukemia (AL) [107 acute myeloid leukemia (AML), 20 acute promyelocytic leukemia (APL) and 27 acute lymphoblastic leukemia (ALL)]. The allelic frequency of the H63D mutation was 29% in AL patients and 25% in the healthy controls [P = 0.41; odds ratio (OR) = 1.20; 95% confidence interval (CI) = 0.77 - 1.93]. No difference was found between controls and AML or APL patients, whereas the H63D mutation was significantly more frequent in ALL than controls (44% vs. 25%, P = 0.04; OR = 2.37; 95% CI = 1.05 - 5.36). The overall comparison of the mutation among the three subtypes of AL demonstrated a higher allelic frequency in ALL (P = 0.02). In conclusion, our data demonstrate a correlation between the presence of the H63D mutation and the occurrence of ALL in adult patients.
Databáze:	OpenAIRE
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