Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012–13, 2013–14, and 2014–15
| Autor: | Stephanie A. Irving, Kayla E. Hanson, Tom T. Shimabukuro, Jennifer P. King, David L. McClure, Edward A. Belongia, Allison L. Naleway, Lisa A. Jackson, Eric Weintraub, Oluwatosin Olaiya, Burney A. Kieke, James G. Donahue, Jason M. Glanz, Rulin C. Hechter, Nicola P. Klein, Frank DeStefano, Maria A. Mascola |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Vaccine safety medicine.medical_specialty Adolescent Influenza vaccination status Influenza vaccine Abortion History 21st Century Article Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Internal medicine Odds Ratio medicine Humans Public Health Surveillance 030212 general & internal medicine Spontaneous abortion General Veterinary General Immunology and Microbiology business.industry Vaccination Public Health Environmental and Occupational Health Odds ratio medicine.disease Influenza Confidence interval Abortion Spontaneous Infectious Diseases Vaccines Inactivated Influenza Vaccines Case-Control Studies Molecular Medicine Female Seasons business |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2019.09.035 |
| Popis: | Introduction A recent study reported an association between inactivated influenza vaccine (IIV) and spontaneous abortion (SAB), but only among women who had also been vaccinated in the previous influenza season. We sought to estimate the association between IIV administered in three recent influenza seasons and SAB among women who were and were not vaccinated in the previous influenza season. Methods We conducted a case-control study over three influenza seasons (2012–13, 2013–14, 2014–15) in the Vaccine Safety Datalink (VSD). Cases (women with SAB) and controls (women with live births) were matched on VSD site, date of last menstrual period, age group, and influenza vaccination status in the previous influenza season. Of 1908 presumptive cases identified from the electronic record, 1236 were included in the main analysis. Administration of IIV was documented in several risk windows, including 1–28, 29–56, and >56 days before the SAB date. Results Among 627 matched pairs vaccinated in the previous season, no association was found between vaccination in the 1–28 day risk window and SAB (adjusted odds ratio (aOR) 0.9; 95% confidence interval (CI) 0.6–1.5). The season-specific aOR ranged from 0.5 to 1.7 with all CIs including the null value of 1.0. Similarly, no association was found among women who were not vaccinated in the previous season; the season-specific aOR in the 1–28 day risk window ranged from 0.6 to 0.7 and the 95% CI included 1.0 in each season. There was no association found between SAB and influenza vaccination in the other risk windows, or when vaccine receipt was analyzed relative to date of conception. Conclusion During these seasons we found no association between IIV and SAB, including among women vaccinated in the previous season. These findings lend support to current recommendations for influenza vaccination at any time during pregnancy, including the first trimester. |
| Databáze: | OpenAIRE |
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