Metformin treatment alters memory function in a mouse model of Alzheimer's disease
| Autor: | Gustavo Dziewczapolski, Kacee A DiTacchio, Stephen F. Heinemann |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Memory Dysfunction Mice Transgenic Disease Bioinformatics Article Amyloid beta-Protein Precursor Mice Alzheimer Disease Diabetes mellitus Internal medicine medicine Animals Humans Hypoglycemic Agents Maze Learning Analysis of Variance Memory Disorders business.industry General Neuroscience AMPK Type 2 Diabetes Mellitus Cognition General Medicine Fasting medicine.disease Metformin Mice Inbred C57BL Psychiatry and Mental health Clinical Psychology Disease Models Animal Endocrinology Mutation Geriatrics and Gerontology business Function (biology) medicine.drug |
| Zdroj: | J Alzheimers Dis |
| ISSN: | 1875-8908 |
| Popis: | Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD. |
| Databáze: | OpenAIRE |
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