The prevalence of ataxia telangiectasia mutated (ATM) variants in patients with breast cancer patients: a systematic review and meta-analysis
Autor: | Yousef Moradi, Masoumeh Moslemi, Marzieh Soheili, Maryam Vafaei, Ehsan Sohrabi, Reza Nedaeinia, Mostafa Manian, Pouria Khani |
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Rok vydání: | 2021 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty BRCA MEDLINE Prevalence Review Breast cancer Internal medicine Genetics medicine In patient RC254-282 ATM variants QH573-671 business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer medicine.disease Confidence interval Meta-analysis Systematic review Cytology business |
Zdroj: | Cancer Cell International Cancer Cell International, Vol 21, Iss 1, Pp 1-9 (2021) |
ISSN: | 1475-2867 |
Popis: | Breast cancer is the most common cancer in women, and its high mortality has become one of the biggest health problems globally. Several studies have reported an association between breast cancer and ATM gene variants. This study aimed to demonstrate and analyze the relationship between ATM gene polymorphisms and breast cancer prevalence rate. A systematic literature review was undertaken using the following databases: Medline (PubMed), Web of sciences, Scopus, EMBASE, Cochrane, Ovid, and CINHAL to retrieve all cross-sectional studies between January 1990 and January 2020, which had reported the frequency of ATM variants in patients with breast cancer. A random-effects model was applied to calculate the pooled prevalence with a 95% confidence interval. The pooled prevalence of ATM variants in patients with breast cancer was 7% (95% CI: 5−8%). Also, the pooled estimate based on type of variants was 6% (95% CI: 4−8%; I square: 94%; P: 0.00) for total variants¸ 0% (95% CI: 0−1%; I square: 0%; P: 0.59) for deletion variants, 12% (95% CI: 7−18%; I square: 99%; P: 0.00) for substitution variants, and 2% (95% CI: 4−9%; I square: 67%; P: 0.08) for insertion variants. This meta-analysis showed that there is a significant relationship between ATM variants in breast cancer patients. Further studies are required to determine which of the variants of the ATM gene are associated with BRCA mutations. |
Databáze: | OpenAIRE |
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