Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?
| Autor: | Silvio Bašić, Jadranka Sertić, Darija Mahović Lakušić, Davor Sporiš, Tomislav Babić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein E2 Apolipoprotein E4 Apolipoprotein E3 lcsh:Medicine Polymorphism genetic Gastroenterology Temporal lobe 03 medical and health sciences Epilepsy Apolipoproteins E 0302 clinical medicine Internal medicine Humans Medicine Age of Onset Allele Alleles Epilepsy temporal lobe Age at Onset business.industry Significant difference lcsh:R Delayed onset Age at onset General Medicine Middle Aged medicine.disease 030104 developmental biology Case-Control Studies Mutation Female lipids (amino acids peptides and proteins) business 030217 neurology & neurosurgery |
| Zdroj: | Acta Clinica Croatica, Vol 56., Iss 1., Pp 10-14 (2017) |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | The aim of the study was to evaluate the possible association between Apo E polymorphisms and age at seizure onset in patients with non-lesional temporal lobe epilepsy. Eighty patients with non-lesional temporal lobe epilepsy with or without bilateral tonic-clonic propagation were analyzed. Age at seizure onset was defined as age at the first unequivocal seizure (excluding febrile convulsions). ApoE alleles were determined by a procedure where genome DNA was amplified by chain reaction along with polymerase, using the LightCycler kit (Roche) for ApoE mutations on codons 112 and 158. There was a statistically significant difference between the groups of patients with ApoE ε2/3 and ε3/4 genotypes (p=0.03), but not between patients with ApoE, ε2/3 and ε3/3, and those with ApoE ε3/4 and ε3/3. In conclusion, the results of our study suggested positive association of a specific ApoE genotype and onset of non-lesional temporal lobe epilepsy. |
| Databáze: | OpenAIRE |
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