Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw
| Autor: | Shunsuke Sawada, Souichi Yanamoto, Sakiko Soutome, Kohei Okuyama, Masahiro Umeda, Akiko Kawakita, Yumi Kawaoka, Suguru Ishida, Hiroshi Iwai, Hirokazu Yutori, Yuka Kojima, Saki Hayashida |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Multivariate analysis Endocrinology Diabetes and Metabolism Radiography Periosteal reaction 030209 endocrinology & metabolism 03 medical and health sciences Osteosclerosis 0302 clinical medicine Endocrinology Risk Factors Periosteum Medicine Humans Orthopedics and Sports Medicine Clinical significance Aged Aged 80 and over business.industry Proportional hazards model General Medicine medicine.disease Surgery Treatment Outcome Orthopedic surgery Bisphosphonate-Associated Osteonecrosis of the Jaw Female 030101 anatomy & morphology business Osteonecrosis of the jaw Tomography X-Ray Computed |
| Zdroj: | Journal of bone and mineral metabolism. 37(5) |
| ISSN: | 1435-5604 |
| Popis: | Regarding treatment strategies for medication-related osteonecrosis of the jaw (MRONJ), surgical therapy has recently been reported to be more effective than conservative therapy. However, some patients did not achieve complete healing, even when extensive surgery was performed. Periosteal reaction in MRONJ patients is often observed by the CT examination. Tssshe purpose of this study was to investigate the relationship between periosteal reaction and treatment outcome of MRONJ. A total of 164 surgeries in 136 patients with MRONJ at two hospitals were included in the study. Correlations between various clinical and radiographic factors and treatment outcome were examined with Cox regression analysis. The results showed that the presence of periosteal reaction, as well as primary disease involving malignant tumor, were independent risk factors related to poor outcome. Furthermore, we examined factors related to the occurrence of the periosteal reaction and found that 4 variables were significantly correlated with periosteal reaction by multivariate analysis: gender (female), site (lower jaw), primary disease (malignant tumor), and osteosclerosis (severe). The present study clarified that the cure rate after surgical treatment decreased in cases with periosteal reaction, suggesting that it is necessary to review the treatment method. |
| Databáze: | OpenAIRE |
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