Evaluation of histological changes after tracheal occlusion at different gestational ages in a fetal rat model
| Autor: | Augusto F. Schmidt, Lourenço Sbragia, Carolina Teixeira de Resende Barreto, Luis Antonio Violin Dias Pereira, Frances Lilian Lanhellas Gonçalves, Rodrigo Melo Gallindo |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Therapeutic Occlusion Time Factors Hernia Experimental Model Tracheomegaly Diaphragmatic breathing Gestational Age Fetus Medicine Animals Lung lcsh:R5-920 business.industry Cartilage Body Weight Age Factors Gestational age Reproducibility of Results General Medicine Anatomy Organ Size respiratory system Rats Trachea medicine.anatomical_structure Basic Research Models Animal Gestation business lcsh:Medicine (General) Diaphragmatic |
| Zdroj: | Clinics, Volume: 68, Issue: 1, Pages: 59-63, Published: JAN 2013 Clinics; v. 68 n. 1 (2013); 59-63 Clinics; Vol. 68 Núm. 1 (2013); 59-63 Clinics; Vol. 68 No. 1 (2013); 59-63 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 68, Iss 1, Pp 59-63 (2013) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: To evaluate the histological changes of tracheal cartilage and epithelium caused by tracheal occlusion at different gestational ages in a fetal rat model. METHODS: Rat fetuses were divided into two groups: a) External control, composed of non-operated rats, and b) Interventional group, composed of rats operated upon on gestational day 18.5 (term = 22 days), divided into triads: 1) Tracheal occlusion, 2) Internal control and 3) Sham (manipulated but not operated). Morphological data for body weight, total lung weight and total lung weight/body weight ratio were collected and measured on gestational days 19.5, 20.5 and 21.5. Tracheal samples were histologically processed, and epithelial, chondral and total tracheal thicknesses were measured on each gestational day. RESULTS: The tracheal occlusion group exhibited an increase in total lung weight/body weight ratio (p |
| Databáze: | OpenAIRE |
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