Vascular Changes in Merkel Cell Carcinoma Based on a Histopathological Study of 92 Cases
| Autor: | Ksenia V Shelekhova, Michal Michal, Radek Sima, Marina Vazmitel, Petr Mukensnabl, Dmitry V. Kazakov |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Dermatology Neuroendocrine tumors Sensitivity and Specificity Pathology and Forensic Medicine Cohort Studies Biopsy Carcinoma medicine Humans Gammaherpesvirinae Aged Neoplasm Staging Retrospective Studies Skin Aged 80 and over Neovascularization Pathologic biology medicine.diagnostic_test Follicular dendritic cells Merkel cell carcinoma business.industry Biopsy Needle food and beverages General Medicine Middle Aged Hyperplasia medicine.disease biology.organism_classification Immunohistochemistry Carcinoma Merkel Cell Microscopy Electron Female Histopathology business |
| Zdroj: | The American Journal of Dermatopathology. 30:106-111 |
| ISSN: | 0193-1091 |
| Popis: | Although prominent vascular proliferation is a known feature of various neuroendocrine tumors, it has not been systematically studied in Merkel cell carcinoma (MCC) of the skin. The purpose of this study was to fully characterize the light microscopic, immunohistochemical, and ultrastructural features of vascular changes associated with MCC and to determine their frequency and differential diagnostic implications. Additionally, the presence of human herpesvirus 8 DNA in the lesional tissue was investigated. Of 92 studied cases of MCC, 18 cases (20%) were found to exhibit foci of prominent vascular changes which were classified into the following 6 patterns: pericyte hyperplasia, pyogenic granuloma-like, hemangioendothelioma-like, epithelioid hemangioma-like, peliosis-like, and follicular dendritic cell tumor-like pattern. In addition, Azzopardi phenomenon was observed. These changes occurred singly or in combination. Human herpesvirus 8 DNA was identified by polymerase chain reaction in none of the 18 cases. It is concluded that prominent vascular proliferations may be seen in 20% of MCC, and thereby, MCC resembles neuroendocrine tumors in other organs. When unduly prominent and encountered in a limited biopsy specimen, vascular alterations may represent a potential diagnostic pitfall, but, on the other hand, they themselves may serve as a clue to the correct diagnosis. Human herpesvirus 8 does not play a role in angiogenesis in MCC. |
| Databáze: | OpenAIRE |
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