Oxidative stress in preeclamptic mother - newborn dyads and its correlation with early neonatal outcome - a case control study
| Autor: | Bobby Zachariah, V. Vickneswaran, Vishnu Bhat, Shruti Bharadwaj, Bethou Adhisivam, Syed Habeebullah |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Physiology 030204 cardiovascular system & hematology Affect (psychology) medicine.disease_cause Infant Newborn Diseases Preeclampsia Correlation 03 medical and health sciences Young Adult 0302 clinical medicine Pre-Eclampsia Pregnancy Medicine Humans Young adult 030219 obstetrics & reproductive medicine business.industry fungi Case-control study Infant Newborn food and beverages Obstetrics and Gynecology medicine.disease Oxidative Stress Case-Control Studies Pediatrics Perinatology and Child Health Female business Protein carbonyl Oxidative stress |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 31(12) |
| ISSN: | 1476-4954 |
| Popis: | Preeclamptic mothers are likely to have increased oxidative stress during pregnancy which can adversely affect the outcome in their neonates.To measure the oxidative stress in preeclamptic mother- newborn dyads and correlate it with the immediate neonatal outcome.This case control study conducted in a tertiary care teaching hospital, South India included 71 preeclamptic mothers - newborn dyads (cases) and 72 normal mothers - newborn dyads (controls). Biochemical parameters including total antioxidant status (TAS), protein carbonyls and malondialdehyde levels (MDA) were measured in both maternal and cord blood. Association between these oxidative stress parameters and early neonatal outcome was studied.All oxidative stress markers were higher in the preeclampsia group compared to the controls. Cord blood protein carbonyl levels had significant correlation with maternal levels. Prematurity, low-birth weight, respiratory distress syndrome (RDS), early onset sepsis (EOS) and intra-uterine growth restriction (IUGR) were more among cases. Early neonatal outcomes like death, IUGR, EOS, and RDS had significant correlation with protein carbonyl levels among the cases.Oxidative stress is increased in preeclamptic mother - newborn dyads. Increased protein carbonyl levels in preeclampsia correlate with adverse early neonatal outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|