An exploratory study to investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in adult males
| Autor: | Harry M. Roberts, Jeanette M. Thom, Julian A. Owen, Lewis Angell, Claire Griffith-Mcgeever, Jonathan P. Moore |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Cartilage Articular Male medicine.medical_specialty Pathology Adolescent Sports medicine Physiology Physical activity Cartilage metabolism Cartilage Oligomeric Matrix Protein 03 medical and health sciences Age 0302 clinical medicine Joint lubrication Physiology (medical) Ultrasound medicine Animals Humans Orthopedics and Sports Medicine Femur Tissue metabolism Hyaluronic Acid Exercise Glycoproteins Ultrasonography 030203 arthritis & rheumatology Cartilage oligomeric matrix protein biology business.industry Cartilage Age Factors Public Health Environmental and Occupational Health General Medicine Middle Aged Knee cartilage thickness medicine.anatomical_structure biology.protein Original Article business Body mass index Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Applied Physiology |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-021-04655-y |
| Popis: | Purpose To investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in a cross-sectional sample of adult males. This study utilizes several emerging biomarkers that have been associated with early joint degenerative changes; serum COMP (cartilage oligomeric matrix protein), HA (hyaluronan) and lubricin. Methods Eighty-one males (age: mean (range): 43(18–70) years; body mass index: 25.2 (21.0–30.6) kg/m2) volunteered. Resting serum COMP, HA and lubricin concentrations were determined via commercially available enzyme-linked immunosorbent assay (ELISA) and femoral trochlear cartilage thickness via supra-patellar ultrasound imaging. Physical activity levels were assessed using questionnaires. Statistical analyses were performed using correlation and regression analyses. Results Age was correlated with lateral trochlear cartilage thickness (r = − 0.372; p r = 0.342; p r = 0.357, p r = 0.340, p = 0.01) and serum HA (r = 0.296, p p > 0.05). Conclusion This study indicates that older age may be associated with thinner lateral trochlear cartilage and higher cartilage turnover. Being physically active may also be positive for lateral trochlear cartilage thickness. However, overall, both age and physical activity level only account for a small amount of the variability in cartilage thickness and serum biomarkers. |
| Databáze: | OpenAIRE |
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