A 5-year prospective study on regenerative periodontal therapy of infrabony defects using minimally invasive surgery and a collagen-enriched bovine-derived xenograft

Autor: Hugo De Bruyn, Jan Cosyn, Faris Younes, Thomas De Bruyckere, Wolfgang Jacquet, Roberto Cleymaet, Aryan Eghbali
Přispěvatelé: Faculty of Medicine and Pharmacy, Surgical clinical sciences, Oral Health, Educational Science, Localities, Ontologies, Commons, Integrated
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Radiography
Oral hygiene
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Minimally invasive surgery
Absorbable Implants
medicine
Animals
Humans
Minimally Invasive Surgical Procedures
Regeneration
Prospective Studies
Prospective cohort study
Initial therapy
General Dentistry
Periodontal Diseases
Medicine(all)
Minerals
business.industry
Patient Selection
Xenograft
Attachment level
Mean age
030206 dentistry
Middle Aged
Oral Hygiene
Surgery
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
Infrabony defect
Treatment Outcome
030104 developmental biology
Bone Substitutes
Invasive surgery
Guided Tissue Regeneration
Periodontal
Heterografts
Patient Compliance
Cattle
Female
Periodontal Index
Periodontal disease
business
Zdroj: Clinical Oral Investigations, 22, 1235-1242
Clinical Oral Investigations, 22, 3, pp. 1235-1242
ISSN: 1432-6981
Popis: Item does not contain fulltext AIM: The primary objective of this study was (1) to evaluate the 5-year clinical outcome of regenerative periodontal therapy (RPT) using minimally invasive surgery and a collagen-enriched bovine-derived xenograft and (2) to identify predictors for clinical attachment level (CAL) gain and vertical radiographic bone (RB) gain. MATERIALS AND METHODS: Ninety-five non-smoking patients with /= 6 months after initial periodontal therapy with >/= 1 isolated interdental infrabony defect were recruited. Minimally invasive surgery (MIST or M-MIST) and a collagen-enriched bovine-derived xenograft were used in all patients. Patients were surgically treated by the same clinician and evaluated up to 5 years of follow-up. Multivariate analyses were used to identify predictors for CAL gain and RB gain. RESULTS: Before surgery, mean probing depth (PD) was 7.8 mm, CAL was 10.0 mm, and defect depth amounted to 5.2 mm. Seventy-one patients (33 men, 38 women, mean age 52) could be evaluated at 5 years. Mean PD reduction was 3.3 mm (SD 2.2), CAL gain was 3.0 mm (SD 2.1), and RB gain was 57% (SD 38). Forty-five percent showed >/= 4 mm CAL gain, whereas 24% were considered failures (/= 75%). Regression analyses showed that plaque was a significant predictor for CAL gain (p = 0.001) and RB gain (p = 0.005). Patients' compliance had a significant impact on RB gain (p < 0.001). CONCLUSION: Only patients with perfect oral hygiene and excellent compliance should be considered for RPT. Especially, the latter can only be assessed after sufficient follow-up following initial periodontal therapy. CLINICAL RELEVANCE: RPT failed in 24% of the patients after 5 years. Regression analyses demonstrated a significant impact of plaque and patients' compliance on the long-term outcome. Only patients with perfect oral hygiene and excellent compliance should be considered for RPT. Patients should not be treated too soon following initial therapy, since compliance can only be reliably assessed after sufficient follow-up.
Databáze: OpenAIRE
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