How do channel- and pore-forming helical peptides interact with lipid membranes and how does this account for their antimicrobial activity?

Autor:	Herve Duclohier
Rok vydání:	2002
Předmět:	Pharmacology Chemistry Lipid Bilayers General Medicine Antimicrobial Ion Channels Structure-Activity Relationship Membrane Anti-Infective Agents Drug Design Drug Discovery Amphiphile Biophysics Drug Interactions Peptides Ion channel
Zdroj:	Mini reviews in medicinal chemistry. 2(4)
ISSN:	1389-5575
Popis:	Animals and plants defend themselves against pathogenic micro-organisms by the rapid mobilization of polycationic helical amphipathic peptides. Interactions with membranes induce optimal orientation and mutual structural changes, allowing for example to form transbilayer ion channels or pores whose properties are compared in this review. Physicochemical studies of peptide-lipid interactions provide attractive approaches for drug design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e047411187ad76d67d6bbbe44945037c https://pubmed.ncbi.nlm.nih.gov/12370054 Zobrazit plný text záznamu