Topical ampicillin in addition to a systemic antibiotic prophylaxis in elective colorectal surgery
| Autor: | U. Merrild, Ole Kronborg, Poul Juul |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Colon medicine.drug_class Administration Topical Premedication Antibiotics Random Allocation Double-Blind Method Colon surgery Metronidazole Ampicillin medicine Humans Surgical Wound Infection Prospective Studies Aged Clinical Trials as Topic business.industry Rectum Gastroenterology Surgical wound General Medicine Middle Aged biochemical phenomena metabolism and nutrition Colorectal surgery Surgery Clinical trial Anesthesia Female business medicine.drug |
| Zdroj: | Diseases of the Colon & Rectum. 28:804-806 |
| ISSN: | 0012-3706 |
| Popis: | Prophylactic use of topical ampicillin in addition to intravenous ampicillin and metronidazole was studied in a randomized trial including 203 consecutive patients undergoing elective colorectal surgery. All received ampicillin, 1 g X 3, and metronidazole, 0.5 g X 3, intravenously for at least three days from induction of anesthesia, and 105 also received topical ampicillin, 1 g, in each of the surgical wounds. Deep wound infection or dehiscence was seen in 12 of 105 having both administrations of antibiotics, and in nine of 98 having only intravenous antibiotics. The two groups were similar according to distribution of sex, age, type of surgery, and efficiency of bowel preparation. Topical ampicillin should be omitted in elective colorectal surgery when systemic prophylaxis with ampicillin and metronidazole is used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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