The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice
| Autor: | Süleyman Dönmezdil, Hasan Akkoc, Mihrab Abul, Emre Uyar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
antidepressant effects
ethyl pyruvate Medicine (General) Chemistry General Mathematics Stress induced brain-derived neurotrophic factor (bdnf) glutathione peroxidase (gpx) forced swimming test R5-920 Health Care Sciences and Services Biophysics Medicine Ethyl pyruvate forced swimming test glutathione peroxidase (GPx) brain-derived neurotrophic factor (BDNF) antidepressant effects Ethyl pyruvate Sağlık Bilimleri ve Hizmetleri Behavioural despair test |
| Zdroj: | Volume: 48, Issue: 3 514-522 Dicle Tıp Dergisi Dicle Medical Journal, Vol 48, Iss 3, Pp 514-522 (2021) |
| ISSN: | 1300-2945 1308-9889 |
| Popis: | Objective: Ethyl pyruvate (EP) is a molecule with antioxidant, anti-inflammatory, and anti-apoptotic features. The present study investigates EP's effects on behavioral and biochemical alterations induced by immobilization (IM) stress. Methods: In this outcome, 45 male BALB/c mice were separated into five groups [CONT (control), IM, IM+EP, EP, IM+F (fluoxetine)]. IM applied groups had 6 hours of immobilization stress procedure a day for a week. EP (50 mg/day) and fluoxetine (5 mg/day) were applied to the mice intraperitoneally. After the stress induction protocol, passive avoidance, open field (OF), and forced swimming tests (FST) were executed. After behavioral tests, brain tissues were obtained for biochemical investigations. Results: Immobilization application increased immobility times in the FST and decreased the total distance moved and the center time in the OF test. Immobile times were reduced with fluoxetine and EP applied groups compared with the IM group due to decreased learned helplessness. The IM group had decreased brain-derived neurotrophic factor (BDNF), superoxide dismutase, and glutathione peroxidase levels, which were increased with EP applications. Conclusion: These results show that EP generates antidepressant-like effects with decreasing oxidation and increasing BDNF levels. |
| Databáze: | OpenAIRE |
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