ANTI-HIV PROPERTIES OF CATIONIC FULLERENE DERIVATIVES
| Autor: | Jan Balzarini, Maurizio Prato, Giampiero Spalluto, Tatiana Da Ros, Silvia Marchesan |
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| Přispěvatelé: | Marchesan, Silvia, DA ROS, Tatiana, Spalluto, Giampiero, J., Balzarini, Prato, Maurizio |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
Anti-HIV Agents Clinical Biochemistry Substituent Pharmaceutical Science Virus Replication Biochemistry Sensitivity and Specificity Cell Line chemistry.chemical_compound Structure-Activity Relationship Isomerism Cations Drug Discovery HIV inhibitor Structure–activity relationship RNA Viruses Cytotoxicity Molecular Biology fullerene Organic Chemistry Cationic polymerization DNA Viruses RNA HIV In vitro chemistry Molecular Medicine Fullerenes Cis–trans isomerism DNA |
| Popis: | A series of regioisomeric bis-fulleropyrrolidines bearing two ammonium groups have been synthesized and their activities against HIV-1 and HIV-2 have been evaluated. Two trans isomers have been endowed with interesting antiviral properties, confirming the importance of the relative positions of the substituent on the C(60) cage. In addition, reduced amphiphilicity of molecules to other compounds previously reported decreases their cytotoxicity in CEM cell cultures. None of the compounds showed any inhibitory activity against a variety of DNA and RNA viruses other than HIV. |
| Databáze: | OpenAIRE |
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