Poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) nanoparticles: preparation, characterization, and application in doxorubicin delivery
| Autor: | YinLan Zhao, Lan Zheng, Maling Gou, Zhiyong Qian, Feng Luo, Ke Men, Xia Zhao, Yuquan Wei, XiuLing Zheng, Juan Zhang, XiuHong Wang |
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| Rok vydání: | 2009 |
| Předmět: |
Polyesters
Nanoparticle macromolecular substances Cell Line Polyethylene Glycols chemistry.chemical_compound Mice Neoplasms PEG ratio Materials Chemistry medicine Copolymer Organic chemistry Animals Humans Doxorubicin Physical and Theoretical Chemistry Drug Carriers Mice Inbred BALB C Antibiotics Antineoplastic technology industry and agriculture Hydrogen-Ion Concentration equipment and supplies musculoskeletal system Surfaces Coatings and Films Rats chemistry Drug delivery Nanoparticles Female Drug carrier Ethylene glycol Caprolactone Nuclear chemistry medicine.drug |
| Zdroj: | The journal of physical chemistry. B. 113(39) |
| ISSN: | 1520-5207 |
| Popis: | Biodegradable poly(epsilon-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymer nanoparticles showed potential application in drug delivery systems. In this article, monodisperse poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) (PCL/PEG/PCL, PCEC) nanoparticles, approximately 40 nm, were prepared by solvent extraction method using acetone as the organic solvent. These PCL/PEG/PCL nanoparticles did not induce hemolysis in vitro and did not show toxicity in vitro or in vivo. The prepared PCL/PEG/PCL nanoparticles were employed to load doxorubicin by a pH-induced self-assembly method. In vitro release study indicated that doxorubicin release from nanoparticles at pH 5.5 was faster than that at pH 7.0. The encapsulation of doxorubicin in PCL/PEG/PCL nanoparticles enhanced the cytotoxicity of doxorubicin on a C-26 cell line in vitro. Meanwhile, compared with free doxorubicin, doxorubicin in nanoparticles could more efficiently treat mice bearing subcutaneous C-26 tumors. The doxorubicin-loaded PCL/PEG/PCL nanoparticles might be a novel doxorubicin formulation for cancer therapy. |
| Databáze: | OpenAIRE |
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