Association between ABCB1 (3435CT) polymorphism and susceptibility of colorectal cancer: A meta-analysis
| Autor: | Baile Zuo, Binghua Tong, Li-li Han, Guo Zhenni, Guoyin Li, Wei-liang Cai, Zheng Zhu, Wei Huilian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Colorectal cancer colorectal cancer Cochrane Library Polymorphism Single Nucleotide ABCB1 gene susceptibility polymorphism 03 medical and health sciences 0302 clinical medicine Meta-Analysis of Observational Studies in Epidemiology Risk Factors Internal medicine Genetic model medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine business.industry Case-control study General Medicine Odds ratio medicine.disease Confidence interval meta-analysis 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies Inclusion and exclusion criteria ComputingMethodologies_DOCUMENTANDTEXTPROCESSING business Colorectal Neoplasms Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text Studies on the relationship between ABCB1 3435C>T polymorphism (rs1045642) and colorectal cancer (CRC)susceptibility have yielded inconclusive results. To clarify this issue, we undertook a meta-analysis to investigate the relationship between rs1045642 and CRC risk. Three electronic scientific publication databases (Cochrane Library, Pubmed, Embase) were screened using specific search terms. Relevant literature was identified using literature traceability methods. Selected publications were evaluated according to the inclusion and exclusion criteria. Effect size information (odds ratio and the corresponding 95% confidence interval [CI]) was obtained following quality assessment and data extraction from the included publications, and a meta-analysis conducted. Statistical analysis was performed with the Stata sofz (Version 13.0) software. Overall, 17 case-control studies involving 7129 CRC patients and 7710 healthy control subjects satisfied the criteria for inclusion in the meta-analysis. There was no significant association between ABCB1 3435C>T polymorphism and CRC risk in any of the genetic models. In the CC versus CT model (I2 = 20.9%, Pheterogeneity = .276), CC versus CT + TT model (I2 = 45.6%, Pheterogeneity = .102) and CT versus CC + TT model (I2 = 17.8%, Pheterogeneity = .298) analyses, between-study heterogeneities were detected as significant in Asian populations. In the CT versus TT model (I2 = 24%, Pheterogeneity = .254) and CC + CT versus TT model (I2 = 0, Pheterogeneity = .55), between-study heterogeneities were found to be significant in groups of different populations. The meta-analysis described here suggests that the ABCB1 3435C>T polymorphism is not related to CRC susceptibility. |
| Databáze: | OpenAIRE |
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