In vitro Approaches to Model Breast Tumor Complexity
| Autor: | Heizel Rosado-Galindo, Maribella Domenech, Lyanne Suarez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL Cancer research Biology GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) In vitro Breast tumor |
| Popis: | Cell culture technologies have provided biomedical researchers with fast and accessible tools to probe the breast tumor microenvironment. Exponential progress in fabrication methods combined with multiparametric approaches have enabled the development of cell culture model systems with enhanced biological complexity to identify key aspects that regulate breast cancer (BC) progression and therapeutic response. Yet, the culture parameters and conditions employed influence the behavior of tumor cells, thereby affecting its tissue biomimetic capabilities. In this chapter we review the wide range of culture platforms employed for the generation of breast tumor models and summarize their biomimetic capabilities, advantages, disadvantages and specific applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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