CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan
| Autor: | Virginie Driss, Marie Delbeke, Monique Capron, Sylvie Loiseau, Yann Guérardel, Laurent Kremer, Fanny Legrand, Emmanuel Hermann, David Dombrowicz |
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| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
Immunology Macrophage-1 Antigen Complement receptor Biology Microbiology Phosphatidylinositol 3-Kinases Immune system Phagocytosis Eosinophil activation medicine Humans Immunology and Allergy Erythropoietin Mycobacterium bovis Innate immune system Lipoarabinomannan respiratory system Eosinophil biology.organism_classification Toll-Like Receptor 2 Eosinophils medicine.anatomical_structure biology.protein Eosinophil peroxidase |
| Zdroj: | Immunology Letters. 143:202-207 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2012.02.011 |
| Popis: | Eosinophils have recently been shown to participate in innate immune responses against mycobacteria. We have investigated whether Mycobacterium bovis BCG regulate the human eosinophil immune response. A negative correlation between mycobacteria internalization and eosinophil activation was observed. In addition, mannose-capped lipoarabinomannan from M. bovis BCG (ManLAM) failed to induce a significant release of eosinophil peroxidase and TNF-α. Noteworthy, ManLAM exhibited a potent inhibitory effect on eosinophil peroxidase release by TLR2-activated eosinophils involving the complement receptor-3 molecule and the phosphatidylinositol-3 kinase pathway. ManLAM, generally present in pathogenic mycobacteria, plays an important role in modulating eosinophil-dependent immune response. |
| Databáze: | OpenAIRE |
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