Assessment of the Minimum Number of Lymph Nodes Needed to Detect Lymph Node Invasion at Radical Nephroureterectomy in Patients With Upper Tract Urothelial Cancer
| Autor: | Pierre Karakiewizc, Wassim Kassouf, Eiji Kikuchi, Francesco Montorsi, Arthur I. Sagalowsky, Vitaly Margulis, Marco Roscigno, Alon Z. Weizer, Jeffery C. Wheat, Jay D. Raman, Karim Bensalah, Richard Zigeuner, Shahrokh F. Shariat, Christian Bolenz, Andrea Haitel, Theresa M. Koppie, Charles C. Guo, Massimo Freschi, Philipp Ströbel, Nazareno Suardi, Cord Langner, Mesut Remzi, Christopher G. Wood, Wareef Kabbani, Mario I. Fernández |
|---|---|
| Přispěvatelé: | Roscigno, Marco, Shariat Shahrokh, F., Freschi, Massimo, Margulis, Vitaly, Karakiewizc, Pierre, Suardi, Nazareno, Remzi, Mesut, Zigeuner, Richard, Bolenz, Christian, Kikuchi, Eiji, Weizer, Alon, Bensalah, Karim, Sagalowsky, Arthur, Koppie Theresa, M., Raman, Jay, Fernandez, Mario, Stroebel, Philipp, Kabbani, Wareef, Langner, Cord, Wheat, Jeffery, Guo Charles, C., Kassouf, Wassim, Haitel, Andrea, Wood Christopher, G., Montorsi, Francesco |
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Urology medicine.medical_treatment Nephrectomy Metastasis medicine Humans Neoplasm Invasiveness Stage (cooking) Lymph node Aged Retrospective Studies Aged 80 and over Carcinoma Transitional Cell Ureteral Neoplasms business.industry Cancer Odds ratio Middle Aged medicine.disease Kidney Neoplasms Surgery Numero sign medicine.anatomical_structure Lymphatic Metastasis Lymph Node Excision Lymphadenectomy Radiology Lymph Ureter business |
| Zdroj: | Urology. 74:1070-1074 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2009.04.084 |
| Popis: | OBJECTIVES To determine whether a minimum number of lymph nodes (LNs) exist to detect lymph node invasion (LNI) in patients undergoing radical nephroureterectomy (RNU) for upper tract urothelial carcinoma. METHODS The study included 551 consecutive patients, from 13 centers worldwide, who underwent RNU and lymphadenectomy (LND) between 1992 and 2006. LND was performed at the discretion of the surgeon. All pathological slides were re-reviewed by uropathologists according to strict criteria. Receiver-operating characteristic curve coordinates were used to determine the probability of diagnosing LNI according to the total number of nodes removed. Additionally, the relationship between the number of nodes removed and the rate of positive LNs was tested in univariate and multivariate logistic regression models. RESULTS Median patient age was 68 years (range: 27-97). Of 551 patients, 140 (25.4%) had positive lymph nodes. Median number of lymph nodes removed was 5 (mean 6.7, range 1-41). The Receiver-operating characteristic coordinates plot indicated that the removal of 13 nodes yielded a 90% probability to detect >= 1 positive LNs. The removal of 8 nodes resulted in a 75% probability of finding >= 1 positive nodes. Removal of > 8 LNs (P = .03; odds ratio 1.49) was independently associated with LN1 after adjusting for pathological stage and grade. CONCLUSIONS Our data indicate that 8 LNs need to be removed at radical nephroureterectomy to achieve a 75% probability of finding >= 1 positive nodes. Further improvement of the specificity of LND will require the removal of more lymph nodes. UROLOGY 74: 1070-1077, 2009. (C) 2009 Elsevier Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect