Immobilized random peptide mixtures exhibit broad antimicrobial activity with high selectivity

Autor:	Shlomo Nir, Tal Stern Bauer, Yuval Oren, Zvi Hayouka, Hadar Cheriker
Rok vydání:	2020
Předmět:	Methicillin-Resistant Staphylococcus aureus High selectivity Peptide Microbial Sensitivity Tests 010402 general chemistry medicine.disease_cause 01 natural sciences Catalysis 03 medical and health sciences Materials Chemistry medicine 030304 developmental biology chemistry.chemical_classification 0303 health sciences Chemistry Metals and Alloys Cationic polymerization Pathogenic bacteria General Chemistry Antimicrobial Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Anti-Bacterial Agents Pseudomonas aeruginosa Ceramics and Composites Hydrophobic and Hydrophilic Interactions Antimicrobial Cationic Peptides
Zdroj:	Chemical communications (Cambridge, England). 56(75)
ISSN:	1364-548X
Popis:	In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues that were immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03e8d9ea1b67e69b099b1f2bb417032 https://pubmed.ncbi.nlm.nih.gov/32959824 Zobrazit plný text záznamu