Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N--S acyl transfer
| Autor: | Chung-Hei Chan, Mona Saadi, Jonathan P. Richardson, Derek Macmillan, Javier Blanc |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Nitrogen Protein Conformation Molecular Sequence Data Oligosaccharides Alkylation Biochemistry Substrate Specificity chemistry.chemical_compound Biomimetic Materials Amino Acid Sequence Physical and Theoretical Chemistry Glycoproteins chemistry.chemical_classification Organic Chemistry Glycopeptides Oligosaccharide Native chemical ligation Combinatorial chemistry Semisynthesis chemistry Thiol Click chemistry Chemical ligation Azide Sulfur |
| Zdroj: | Organicbiomolecular chemistry. 8(6) |
| ISSN: | 1477-0539 |
| Popis: | Sugars and simplified oligosaccharide “mimics” can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|