Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α
| Autor: | Clayton Franco Moraes, Juliana Oliveira Toledo, Audrey C Tonet-Furioso, Vinícius Carolino Souza, Cláudio Córdova, Luís Carlos Crocco Afonso, Otávio de Toledo Nóbrega |
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| Jazyk: | portugalština |
| Rok vydání: | 2015 |
| Předmět: |
Drug
medicine.medical_specialty hypertension medicine.drug_class media_common.quotation_subject Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Blood Pressure Proinflammatory cytokine Basal (phylogenetics) Interferon-gamma Pharmacotherapy Internal medicine medicine cytokine Humans guidelines Prospective Studies Prospective cohort study Interleukin 6 Antihypertensive drug Diuretics renin–angiotensin system Antihypertensive Agents media_common Original Research Aged biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha General Medicine Middle Aged Calcium Channel Blockers drug therapy Postmenopause Endocrinology Blood pressure inflammation Clinical Interventions in Aging Hypertension biology.protein Drug Therapy Combination Female Geriatrics and Gerontology Inflammation Mediators Renin-angiotensin system business Brazil |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP Clinical Interventions in Aging |
| Popis: | Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in Medical Sciences, University of Brasília, Brasília, 3Graduate Program in Gerontology, Catholic University of Brasília, Brasília, 4Research Center in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil Objective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control.Methods: Prospective study involving 110 hypertensive, community-dwelling older women with different metabolic disorders. A short-term BP-lowering drug therapy was conducted according to current Brazilian guidelines on hypertension, and basal cytokine levels were measured before and after intervention.Results: Interventions were found to represent current hypertension-management practices in Brazil and corresponded to a significant reduction in systolic and diastolic BP levels in a whole-group analysis, as well as when users and nonusers of the most common therapeutic classes were considered separately. Considering all patients, mean IL-6 and TNF-α levels showed a significant decrease in circulating concentrations (P |
| Databáze: | OpenAIRE |
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