Metastatic malignant peripheral nerve sheath tumor in a newborn
| Autor: | Jan de Kraker, Milco C. de Jonge, Lukas A. Lisowski, Chantal M. A. M. van der Horst, Jos Bras, Jos A. M. Bramer |
|---|---|
| Přispěvatelé: | Other Research, Orthopedic Surgery and Sports Medicine, Amsterdam Cardiovascular Sciences, Plastic, Reconstructive and Hand Surgery, Paediatric Oncology |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Radiography Biopsy Fine-Needle Malignant peripheral nerve sheath tumor Soft Tissue Neoplasms Nerve Sheath Neoplasms Fine needle biopsy Diagnosis Differential Fatal Outcome medicine Humans Survival rate Knee amputation business.industry Foot Forefoot Infant Newborn Soft tissue Hematology medicine.disease Prognosis medicine.anatomical_structure Oncology Abdominal Neoplasms Lymphatic Metastasis Pediatrics Perinatology and Child Health Abdomen Female Radiology Lymph Nodes business Tomography X-Ray Computed |
| Zdroj: | Journal of pediatric hematology/oncology, 30(12), 891-895. Lippincott Williams and Wilkins |
| ISSN: | 1536-3678 1077-4114 |
| Popis: | Malignant peripheral nerve sheath tumors are rare tumors, especially in the newborn period. Diagnosis is based on clinical findings, radiography, and fine needle biopsy or tissue sampling. Ideal management is controversial and extremely difficult. The survival rate is extremely low. We present a case of a newborn in which this tumor is diagnosed in the first few days of life as an ulcerating tumor imbedded in the entire forefoot with already metastatic spread to the lymph nodes and abdomen. Questions arose on the best treatment in postpartum life. Below the knee amputation was performed for nursing purposes, but eventually a no-intention-to treat policy was chosen by the multidisciplinary team and parents. Detection of soft tissue tumors in the prenatal period is difficult and not as easy as for other structural defects. Would prenatal detection have changed the course of life of this young infant? Will future opportunities for detection of soft tissue tumors occur? Diagnostic and therapeutic considerations are discussed alongside the present literature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|