A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study
| Autor: | Georg Juckel, Carsten Spitzer, Kim Bartholdi, Jörg Zimmermann, Heike Anderson-Schmidt, Andreas J. Fallgatter, Urs Heilbronner, Milena Meyers, Thomas G. Schulze, Detlef E. Dietrich, Peter Falkai, Markus M. Nöthen, Manfred Koller, Jens Wiltfang, Eva C. Schulte, Silke Quast, Markus Reitt, Carsten Konrad, Thomas Becker, Volker Arolt, Katrin Gade, Sergi Papiol, Farah Klöhn-Saghatolislam, Daniela Reich-Erkelenz, Stephanie H. Witt, Moritz E. Wigand, Monika Budde, Bernhard T. Baune, Sebastian Stierl, Andreas Thiel, Laura Flatau, Anna Gryaznova, Udo Dannlowski, Markus Jäger, Fabian U. Lang, Ashley L. Comes, Till F. M. Andlauer, Marcella Rietschel, Kristina Adorjan, Ida Sybille Haußleiter, Franziska Degenhardt, Max Schmauß, Janos Kalman, Christian Figge, Harald Scherk, Eva Z. Reininghaus, Jens Reimer, Martin von Hagen, Sophia Stegmaier, Here Folkerts, Andreas J. Forstner, Fanny Senner, Ion-George Anghelescu, Sybille Schulz, Vanessa Nieratschker, Barbara Emons, Maria Hake |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
psychiatry_mental_health_studies
medicine.medical_specialty Psychosis business.industry medicine.disease 030227 psychiatry 3. Good health 03 medical and health sciences 0302 clinical medicine Schizophrenia mental disorders medicine Polygenic risk score Psychiatry business 030217 neurology & neurosurgery Depression (differential diagnoses) |
| Popis: | In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genetic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing the potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study, an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. Within the DSM-IV framework, we compare two broad diagnostic groups: one consisting of predominantly affective and one of predominantly psychotic disorders. Depressive, manic, and psychotic symptoms as well as global functioning over time were analyzed. Furthermore, we explore the effects of polygenic risk scores for schizophrenia on diagnostic group membership and address their effects on non-participation in follow-up visits. While phenotypic results show differences in both current psychotic and manic symptoms, depressive symptoms did not vary between both groups. Polygenic risk scores for schizophrenia significantly explained part of the variability of the diagnostic group. Furthermore, there was a trend that a higher polygenic loading for schizophrenia was associated with attrition. Because of its unique properties, the PsyCourse study presents a prime resource for the interrogation of complex genotype-phenotype relationships. |
| Databáze: | OpenAIRE |
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