Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation pattern
| Autor: | Liron Miller, Natasha Barth, Inbal Farkash, Tali Feferman, Asaf Biber, Yahel Avraham, Grace Mayuni, Dror S. Shouval, Ilya Kirgner, Rony Dahan, Noy Cohen-Saban, David Morgenstern, Yaniv Lustig, Yishai Levin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Glycosylation COVID-19 Vaccines QH301-705.5 IgG glycosylation Vaccine Efficacy Biology Antibodies Viral General Biochemistry Genetics and Molecular Biology Subclass Article chemistry.chemical_compound Humans antibodies complement Israel Biology (General) Receptor Fc-Glycosylation BNT162 Vaccine Aged IgG-Fc Vaccines Synthetic BNT162b2 mRNA vaccine Fcγ receptors Effector SARS-CoV-2 Vaccination COVID-19 Middle Aged Vaccine efficacy immunity Complement system chemistry Immunoglobulin G Immunology Spike Glycoprotein Coronavirus biology.protein Female mRNA Vaccines Antibody effector function |
| Zdroj: | Cell Reports, Vol 37, Iss 11, Pp 110114-(2021) Cell Reports |
| ISSN: | 2211-1247 |
| Popis: | Messenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions are determined by their constant region subclasses and by their glycosylation patterns, but their role in vaccine efficacy is unclear. Moreover, whether vaccination induces antibodies similar to those in patients with COVID-19 remains unknown. We analyze BNT162b2 vaccine-induced IgG subclass distribution and Fc glycosylation patterns and their potential to drive effector function via Fcγ receptors and complement pathways. We identify unique and dynamic pro-inflammatory Fc compositions that are distinct from those in patients with COVID-19 and convalescents. Vaccine-induced anti-Spike IgG is characterized by distinct Fab- and Fc-mediated functions between different age groups and in comparison to antibodies generated during natural viral infection. These data highlight the heterogeneity of Fc responses to SARS-CoV-2 infection and vaccination and suggest that they support long-lasting protection differently. Graphical abstract The Fc structures of IgGs produced during infection and vaccination have important roles in shaping the immune response. Farkash et al. show that vaccine- and infection-induced anti-SARS-CoV-2 IgGs differ in their Fc regions and in the engagement of complement and Fc receptors, implying distinct effector functions and immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|