Hydroxypropyl Methylcellulose-Based Hydrogel Copolymeric for Controlled Delivery of Galantamine Hydrobromide in Dementia

Autor: Noureddine Lebaz, Nadiah Zafar, Asif Mahmood, Abdelhamid Elaissari, Sidra Bashir
Přispěvatelé: University of Lahore, Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique (LAGEPP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Thermogravimetric analysis
Drug Liberation
Radical polymerization
methylene bisacrylamide
Bioengineering
02 engineering and technology
macromolecular substances
galantamine hydrobromide (GH)
010402 general chemistry
lcsh:Chemical technology
complex mixtures
01 natural sciences
lcsh:Chemistry
chemistry.chemical_compound
Differential scanning calorimetry
HPMC
medicine
Chemical Engineering (miscellaneous)
lcsh:TP1-1185
Acrylic acid
pectin
Process Chemistry and Technology
technology
industry
and agriculture
021001 nanoscience & nanotechnology
3. Good health
0104 chemical sciences
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
[CHIM.POLY]Chemical Sciences/Polymers
chemistry
lcsh:QD1-999
Self-healing hydrogels
Galantamine Hydrobromide
Swelling
medicine.symptom
hydrogel
0210 nano-technology
Nuclear chemistry
dementia
Zdroj: Processes, Vol 8, Iss 1350, p 1350 (2020)
Processes
Processes, MDPI, 2020, 8 (11), pp.1350. ⟨10.3390/pr8111350⟩
Volume 8
Issue 11
ISSN: 2227-9717
DOI: 10.3390/pr8111350⟩
Popis: The study aims to prepare a smart copolymeric for controlled delivery of Galantamine hydrobromide. The synthesis of the hydrogel was executed through free radical polymerization using HPMC (Hydroxypropyl methylcellulose) and pectin as polymers and acrylic acid as monomer. Cross-linking was performed by methylene bisacrylamide (MBA). HPMC-pectin-co-acrylic acid hydrogel was loaded with Galantamine hydrobromide (antidementia drug) as a model drug for treatment of Alzheimer based dementia. Formulated hydrogels (SN1&ndash
SN9) were characterized for Fourier transform-infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, and energy dispersive X-ray. Drug loading efficiency, gel fraction, measurements of porosity, and tensile strength were reported. Swelling and release studies were performed at pH 1.2 and 7.4. Drug liberation mechanism was evaluated by applying different release kinetic models. Galantamine hydrobromide was released from prepared hydrogels by Fickian release mechanism. Swelling, gel fraction, porosity, and drug release percentages were found to be dependent on hydroxypropyl methylcellulose, pectin, acrylic acid, and methylene bisacrylamide concentrations. By increasing HPMC amount, swelling was increased from 76.7% to 95.9%. Toxicity studies were conducted on albino male rabbits for a period of 14 days. Hematological and histopathological studies were carried out to evaluate safety level of hydrogel. Successfully prepared HPMC-pectin-co-acrylic acid hydrogel showed good swelling and release kinetics, which may help greatly in providing controlled release drug effect leading to enhanced patient compliance for dementia patients.
Databáze: OpenAIRE
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