In Vivo Confocal Microscopy of Keratic Precipitates
| Autor: | Stephen J. Planck, Justine R. Smith, James T. Rosenbaum, Michael S. Wertheim, Eric B. Suhler, William D. Mathers, Tammy M. Martin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Confocal Corneal Diseases Uveitis Ophthalmology Cornea Humans Medicine Aged Aged 80 and over Microscopy Confocal business.industry Endothelium Corneal Uveomeningoencephalitic Syndrome Middle Aged medicine.disease Toxoplasmosis Precipitins medicine.anatomical_structure Herpes Zoster Ophthalmicus Female Cytomegalovirus retinitis Sarcoidosis business |
| Zdroj: | Archives of Ophthalmology. 122:1773 |
| ISSN: | 0003-9950 |
| Popis: | Objective To evaluate the heterogeneity of keratic precipitates (KP) in varyingsubtypes of uveitis by in vivo confocal microscopy (IVCM). Methods The KP were viewed with a scanning confocal microscope in patients (n = 33)who sought care at a tertiary referral uveitis service for immune-mediatedand infectious forms of uveitis, including HLA-B27–associated uveitis,sarcoidosis, Vogt-Koyanagi-Harada syndrome, juvenile chronic arthritis, Fuchsheterochromic iridocyclitis, cytomegalovirus retinitis, herpes zoster ophthalmicus,ocular toxoplasmosis, and idiopathic uveitis. Images were captured and digitalizedin real time. Results Forty-two eyes of 33 patients were examined in this study. Patient ageranged from 22 to 84 years, with a mean age of 49.4 years. Seventeen (52%)of the patients were women, and 16 patients (48%) were men. The KP rangedin diameter from 10 to 350 μm. We observed the following absolute andspeculative outcomes: KP are markedly heterogeneous and variable as documentedby IVCM; KP in individual patients are consistent throughout the cornea; themorphologic features of KP change across time; infectious vs noninfectiouscauses of uveitis seem to be readily distinguishable by using IVCM; and KPmay have consistency for specific disease states and therefore may have diagnosticimportance. Conclusions To our knowledge, this is the first time that IVCM has been used todescribe the architecture and heterogeneity of KP in uveitis. Such observationsreveal a heterogeneity that could not be appreciated by conventional slitlampmicroscopy and may have diagnostic relevance. |
| Databáze: | OpenAIRE |
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