Chlamydial Genovar Distribution after Communitywide Antibiotic Treatment
| Autor: | Julius Schachter, Jianzhi Zhang, Stephanie Rasmussen, Sue Kalman, Claudia J. Lammel, Deborah L. Bain, Jun Fan, Thomas M. Lietman, Richard S. Stephens, Chandler R. Dawson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
DNA
Bacterial Rural Population medicine.medical_specialty Chlamydia trachomatis Disease Azithromycin medicine.disease_cause Polymerase Chain Reaction Conjunctivitis Bacterial Internal medicine Epidemiology medicine Humans Immunology and Allergy Chlamydiaceae Molecular Epidemiology Chlamydia biology Sequence Analysis DNA Chlamydia Infections Tetracycline biology.organism_classification medicine.disease eye diseases Anti-Bacterial Agents Infectious Diseases Trachoma Chlamydiales Immunology Bacterial Outer Membrane Proteins medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 184:1581-1588 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of . 1 genovar within households was common, with > 24% of households having . 1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars. Trachoma, an eye disease common in many developing countries, is a leading cause of preventable blindness worldwide. An estimated 150 million people are affected by trachoma, of whom 6 million are irreversibly blinded or severely visually disabled by the disease. Trachoma is caused by Chlamydia trachomatis, an obligate intracellular pathogen that infects conjunctival epithelial cells. In areas of endemic infection, most children have been infected by 1 year of age, and active infection is persistent or intermittent throughout the early years of childhood [1]. The risk factors associated with active trachoma for individuals include young age and a sibling with an active infection; those for communities include rural and economically poor locales and lack of access to water [2]. Household clustering of |
| Databáze: | OpenAIRE |
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