Bladder acellular matrix graft: in vivo functional properties of the regenerated rat bladder

Autor: Hans J. Piechota, Curtis A. Gleason, Tom F. Lue, Rajvir Dahiya, L. Nunes, Emil A. Tanagho, S. E. Dahms
Rok vydání: 1999
Předmět:
Nephrology
Male
medicine.medical_treatment
Biocompatible Materials
Regenerative Medicine
urologic and male genital diseases
Rats
Sprague-Dawley
Cystography
Materials Testing
Scanning
bladder
media_common
Microscopy
medicine.diagnostic_test
Cystometry
Urology & Nephrology
female genital diseases and pregnancy complications
Extracellular Matrix
in vivo
homologous
Homologous
Urologic Diseases
medicine.medical_specialty
Urology
media_common.quotation_subject
Urinary Bladder
Clinical Sciences
Renal and urogenital
Urination
Electron
Cystectomy
In vivo
Internal medicine
Key words Bladder
medicine
Animals
Regeneration
Urothelium
Original Paper
Transplantation
Urinary Bladder Calculi
business.industry
graft function
Rats
Microscopy
Electron
Scanning
Sprague-Dawley
Graft function
business
transplantation
Zdroj: Urological research, vol 27, iss 3
Urological Research
Popis: The purpose of this study was to determine whether the rat urinary bladder augmented by an acellular matrix graft can restore the bladder's low-pressure reservoir function and preserve normal micturition. After partial cystectomy (> 50%) and grafting with the bladder acellular matrix graft (BAMG), storage and voiding functions were monitored in 20 rats by means of a specially designed "micturition cage," leak-point cystography, and cystometry. After 4 months, sections (n = 6) were examined histologically to evaluate regeneration of bladder wall components within the BAMG. Bladder capacity and compliance increased progressively and were significantly higher in the grafted animals than in controls (partial cystectomy only), and volumes per void were significantly higher than in either control or normal animals. At 4 months, the regenerated urothelium, smooth muscle, blood vessels and nerves within the BAMG were qualitatively identical to normal bladder wall. Augmentation cystoplasty with the homologous BAMG leads to morphologic and functional rat bladder regeneration, thus enhancing low-pressure reservoir function and preserving normal micturition.
Databáze: OpenAIRE
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