Strain ratio ultrasound elastography increases the accuracy of colour-Doppler ultrasound in the evaluation of Thy-3 nodules. A bi-centre university experience
| Autor: | Carlo Catalano, Elisa Giannetta, Fabrizio Maria Frattaroli, Mattia Di Segni, Giorgio Di Rocco, Andrea M. Isidori, Corrado De Vito, Hektor Grazhdani, Piero Maceroni, Vito Cantisani, Adriano Redler, Ferdinando D'Ambrosio, Laura Giacomelli, Vito D'Andrea, Gregorio Patrizi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Thyroid nodules medicine.medical_specialty ultrasound strain elastography Adolescent thy3 thyroid nodules 030209 endocrinology & metabolism indeterminate cytology Sensitivity and Specificity 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine strain ratio Cytology medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Thyroid Nodule Ultrasonography Doppler Color Aged Neuroradiology Aged 80 and over medicine.diagnostic_test Receiver operating characteristic Strain (chemistry) business.industry ultrasound Ultrasound General Medicine Middle Aged medicine.disease ROC Curve Elasticity Imaging Techniques Female Elastography Radiology business Indeterminate |
| Popis: | To assess whether ultrasound elastography (USE) with strain ratio increases diagnostic accuracy of Doppler ultrasound in further characterisation of cytologically Thy3 thyroid nodules. In two different university diagnostic centres, 315 patients with indeterminate cytology (Thy3) in thyroid nodules aspirates were prospectively evaluated with Doppler ultrasound and strain ratio USE before surgery. Ultrasonographic features were analysed separately and together as ultrasound score, to assess sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Receiver operating characteristic (ROC) curves to identify optimal cut-off value of the strain ratio were also provided. Diagnosis on a surgical specimen was considered the standard of reference. Higher strain ratio values were found in malignant nodules, with an optimum strain ratio cut-off of 2.09 at ROC analysis. USE with strain ratio showed 90.6 % sensitivity, 93 % specificity, 82.8 % PPV, 96.4 % NPV, while US score yielded a sensitivity of 52.9 %, specificity of 84.3 %, PPV 55.6 % and NPV 82.9 %. The diagnostic gain with strain ratio was statistically significant as proved by ROC areas, which was 0.9182 for strain ratio and 0.6864 for US score. USE with strain ratio should be considered a useful additional tool to colour-Doppler US, since it improves characterisation of thyroid nodules with indeterminate cytology. • Strain ratio measurements improve differentiation of thyroid nodules with indeterminate cytology • Elastography with strain ratio is more reliable than ultrasound features and ultrasound score • Strain ratio may help to better select patients with Thy 3 nodules candidate for surgery |
| Databáze: | OpenAIRE |
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