Opioidergic Modulation of Striatal Circuits, Implications in Parkinson's Disease and Levodopa Induced Dyskinesia
| Autor: | Raffaella Tonini, Stefania Sgroi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
signaling pathway Parkinson's disease striatum Striatum Dynorphin Review Biology Neurotransmission lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Dopamine medicine lcsh:Neurology. Diseases of the nervous system Levodopa-induced dyskinesia synaptic plasticity opioids medicine.disease 030104 developmental biology Dyskinesia nervous system Neurology Synaptic plasticity Neurology (clinical) medicine.symptom dopamine Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 9 (2018) |
| ISSN: | 1664-2295 |
| Popis: | The functional organization of the dorsal striatum is complex, due to the diversity of neural inputs that converge in this structure and its subdivision into direct and indirect output pathways, striosomes and matrix compartments. Among the neurotransmitters that regulate the activity of striatal projection neurons (SPNs), opioid neuropeptides (enkephalin and dynorphin) play a neuromodulatory role in synaptic transmission and plasticity and affect striatal-based behaviors in both normal brain function and pathological states, including Parkinson's disease (PD). We review recent findings on the cell-type-specific effects of opioidergic neurotransmission in the dorsal striatum, focusing on the maladaptive synaptic neuroadaptations that occur in PD and levodopa-induced dyskinesia. Understanding the plethora of molecular and synaptic mechanisms underpinning the opioid-mediated modulation of striatal circuits is critical for the development of pharmacological treatments that can alleviate motor dysfunctions and hyperkinetic responses to dopaminergic stimulant drugs. |
| Databáze: | OpenAIRE |
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