12-Month Retrospective Comparison of Kahook Dual Blade Excisional Goniotomy with Istent Trabecular Bypass Device Implantation in Glaucomatous Eyes at the Time of Cataract Surgery
| Autor: | Inder Paul Singh, Leonard K. Seibold, Malik Y. Kahook, Syril Dorairaj, Blake K. Williamson, Mohammed K. ElMallah |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Intraocular pressure medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment iStent Glaucoma Subgroup analysis Ocular Hypotension Trabeculectomy Cataract Extraction Cataract Perioperative Care Tonometry Ocular Trabecular Meshwork Internal medicine Ophthalmology medicine Glaucoma surgery Humans Angle surgery Pharmacology (medical) Case Series Adverse effect Retrospective Studies business.industry Kahook Dual Blade MIGS General Medicine Cataract surgery medicine.disease Rheumatology eye diseases Treatment Outcome Goniotomy Female sense organs medicine.symptom business |
| Zdroj: | Advances in Therapy |
| ISSN: | 1865-8652 |
| Popis: | Purpose To compare the efficacy and safety of combined cataract extraction and either excisional goniotomy performed with the Kahook Dual Blade (KDB; phaco-KDB group) or single iStent trabecular bypass implantation (phaco-iStent group) in eyes with mild to moderate glaucoma and visually significant cataract. Methods This was a retrospective analysis of 315 eyes from 230 adults with mild or moderate glaucoma treated with one or more intraocular pressure (IOP)-lowering medications (190 eyes of 134 subjects in the phaco-KDB group and 125 eyes of 96 subjects in the phaco-iStent group) that required no subsequent surgical intervention for IOP control through 12 months of follow-up. Data included best-corrected visual acuity (BCVA), IOP, and IOP-lowering medications, collected preoperatively and at 1 week and 1, 3, 6, and 12 months postoperatively as well as intraoperative and postoperative adverse events. The primary efficacy outcomes were the proportion of subjects in each group achieving ≥ 20% IOP reduction and ≥ 1 medication reduction at month 12. Subgroup analysis by baseline IOP (≤ 18 mmHg vs. > 18 mmHg) was also performed. Results Mean (standard error) baseline IOP was 18.2 (0.3) mmHg in the phaco-KDB group and 16.7 (0.3) mmHg in the phaco-iStent group (p = 0.001). Statistically significant mean IOP and mean IOP medication reductions from baseline were achieved at all time points in both groups. Mean IOP reductions were significantly greater in the phaco-KDB group than in the phaco-iStent group at all time points including month 12 [− 5.0 (0.3) mmHg vs. − 2.3 (0.4) mmHg, p |
| Databáze: | OpenAIRE |
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