High-performance liquid chromatography–electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products
| Autor: | N Fuzzati, I Strepponi, B Gabetta, F Villa |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adhyperforin
Spectrometry Mass Electrospray Ionization Electrospray Chromatography Plant Extracts Terpenes Electrospray ionization Organic Chemistry Phloroglucinol Hypericum perforatum General Medicine Mass spectrometry Biochemistry High-performance liquid chromatography Analytical Chemistry Bridged Bicyclo Compounds chemistry.chemical_compound Hyperforin chemistry Chromatography High Pressure Liquid Hypericum |
| Zdroj: | Journal of Chromatography A. 926:187-198 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(01)01000-7 |
| Popis: | The alcoholic extract of the aerial parts of Hypericum perforatum L. finds wide application because of its antidepressant activity. The extract contains a number of constituents with documented biological activity including chlorogenic acid, a broad range of flavonoids, naphthodianthrones and phloroglucinols. Hyperforin and adhyperforin are the major phloroglucinol constituents found in the lipophilic fraction of the extracts. Since the stability of hyperforin has been shown to be limited, an investigation of the hyperforin degradation products using HPLC-electrospray ionization mass spectrometry and multiple mass spectrometry was undertaken. |
| Databáze: | OpenAIRE |
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