Childhood cancer and nuclear power plants in Switzerland: a census-based cohort study

Autor: Ben D, Spycher, Martin, Feller, Marcel, Zwahlen, Martin, Röösli, Nicolas X, von der Weid, Heinz, Hengartner, Matthias, Egger, Claudia E, Kuehni, M, Oris
Přispěvatelé: Swiss Paediatric Oncology Group, Swiss National Cohort Study Group, Angst, R., Paulussen, M., Kuehne, T., Brazzola, P., Hirt, A., Leibundgut, K., Ozsahin, AH., Beck Popovic, M., von der Weid NX., Nobile Buetti, L., Rischewski, J., Caflisch, U., Greiner, J., Hengartner, H., Grotzer, M., Niggli, F., Gutzwiller, F., Bopp, M., Faeh, D., Egger, M., Clough-Gorr, K., Schmidlin, K., Spoerri, A., Sturdy, M., Zwahlen, M., Künzli, N., Paccaud, F., Oris, M., University of Zurich, Kuehni, C E
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Pediatrics
Epidemiology
030218 nuclear medicine & medical imaging
Cohort Studies
0302 clinical medicine
Residence Characteristics
Risk Factors
Radiation
Ionizing
Neoplasms
Medicine
Registries
Child
Leukemia
Radiation-Induced
education.field_of_study
Childhood Cancer Registry
Geography
Child Health
Censuses
General Medicine
Environmental exposure
Census
Nuclear power
3. Good health
030220 oncology & carcinogenesis
Child
Preschool
Nuclear Power Plants
Cohort
leukaemia
symbols
Regression Analysis
Female
ionizing radiation
Switzerland
Cohort study
Adolescent
Air Pollutants
Radioactive/adverse effects
Environmental Exposure/adverse effects
Humans
Infant
Infant
Newborn
Leukemia
Radiation-Induced/epidemiology
Leukemia
Radiation-Induced/etiology
Neoplasms/chemically induced
Neoplasms/epidemiology
Switzerland/epidemiology
medicine.medical_specialty
Population
Childhood cancer
610 Medicine & health
population based
03 medical and health sciences
symbols.namesake
Environmental health
cancer
cancer registry
Poisson regression
education
business.industry
Cancer
Environmental Exposure
medicine.disease
Childhood
Cancer registry
10036 Medical Clinic
Air Pollutants
Radioactive
business
Nuclear medicine
2713 Epidemiology
Zdroj: International Journal of Epidemiology
International Journal of Epidemiology, vol. 40, no. 5, pp. 1247-1260
Int.J.Epidemiol.
Spycher, Ben D; Feller, Martin; Zwahlen, Marcel; Röösli, Martin; von der Weid, Nicolas X; Hengartner, Heinz; Egger, Matthias; Kuehni, Claudia E (2011). Childhood cancer and nuclear power plants in Switzerland: a census-based cohort study. International journal of epidemiology, 40(5), pp. 1247-1260. Oxford: Oxford University Press 10.1093/ije/dyr115
ISSN: 1464-3685
0300-5771
DOI: 10.1093/ije/dyr115
Popis: BACKGROUND: Previous studies on childhood cancer and nuclear power plants (NPPs) produced conflicting results. We used a cohort approach to examine whether residence near NPPs was associated with leukaemia or any childhood cancer in Switzerland. METHODS: We computed person-years at risk for children aged 0-15 years born in Switzerland from 1985 to 2009, based on the Swiss censuses 1990 and 2000 and identified cancer cases from the Swiss Childhood Cancer Registry. We geo-coded place of residence at birth and calculated incidence rate ratios (IRRs) with 95% confidence intervals (CIs) comparing the risk of cancer in children born 15 km away, using Poisson regression models. RESULTS: We included 2925 children diagnosed with cancer during 21 117 524 person-years of follow-up; 953 (32.6%) had leukaemia. Eight and 12 children diagnosed with leukaemia at ages 0-4 and 0-15 years, and 18 and 31 children diagnosed with any cancer were born 15 km away, the IRRs (95% CI) for leukaemia in 0-4 and 0-15 year olds were 1.20 (0.60-2.41) and 1.05 (0.60-1.86), respectively. For any cancer, corresponding IRRs were 0.97 (0.61-1.54) and 0.89 (0.63-1.27). There was no evidence of a dose-response relationship with distance (P > 0.30). Results were similar for residence at diagnosis and at birth, and when adjusted for potential confounders. Results from sensitivity analyses were consistent with main results. CONCLUSIONS: This nationwide cohort study found little evidence of an association between residence near NPPs and the risk of leukaemia or any childhood cancer.
Databáze: OpenAIRE
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