Infusion of Cold Saline into the Carotid Artery Does Not Affect Outcome After Intrastriatal Hemorrhage
| Autor: | Andrew M. Demchuk, Mohammed A. Almekhlafi, Frederick Colbourne, Christine A. Dirks, Brittany J Prokop, Lane J Liddle |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system diseases Carotid arteries medicine.medical_treatment Brain Edema Critical Care and Intensive Care Medicine Affect (psychology) Neuroprotection Rats Sprague-Dawley Hypothermia Induced Edema brain temperature Animals Humans Medicine Saline Cerebral Hemorrhage Intracerebral hemorrhage business.industry food and beverages nutritional and metabolic diseases Original Articles Hypothermia medicine.disease intracerebral hemorrhage Rats Disease Models Animal Carotid Arteries Anesthesiology and Pain Medicine intra-arterial chilled saline Anesthesia neuroprotection medicine.symptom business hypothermia edema |
| Zdroj: | Therapeutic Hypothermia and Temperature Management |
| ISSN: | 2153-7933 2153-7658 |
| Popis: | Localized brain hypothermia (HYPO) can be achieved by infusing cold saline into the carotid artery of animals and patients. Studies suggest that HYPO improves behavioral and histological outcomes in focal ischemia models. Given that ischemic stroke and intracerebral hemorrhage (ICH) share pathophysiological overlap, we tested whether cold saline infusion is safe and neuroprotective when given during collagenase-induced ICH. Eighty-five adult male Sprague-Dawley rats were used. Experiment 1 investigated brain and body temperature changes associated with a cold saline infusion paradigm that was scaled from patients according to brain weight and blood volume (3 mL/20-minute infusion). Experiment 2 determined whether HYPO aggravated bleeding volume. Experiment 3 investigated if cerebral edema or elemental concentrations were altered by HYPO. We also collected core body temperature and activity data through telemetry. Experiment 4 investigated whether behavioral outcomes (e.g., skilled reaching) and tissue loss were influenced by HYPO. Our HYPO protocol decreased the ipsilateral striatal temperature by ∼0.20°C (p 0.05 for all). Brain tissue loss was not different between groups on day 28 post-ICH (p = 0.90). Although cold saline infusion appears to be safe in the acute post-ICH period, there was no evidence that this therapy improved outcome. However, our treatment protocol was relatively mild and additional interventions might help improve efficacy. Finally, our findings may also speak to the safety of this cooling approach in focal ischemia where hemorrhagic transformation is a risk; future studies on this issue are needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|