Fungal biotransformation of ezetimibe
| Autor: | Kashif Iqbal, Barkat Ali Khan, Adeel Arshad, Najm Ul Hassan Khan, Irfan Pervaiz, Saeed Ahmad, Wajahat Mahmood, Aftab Ullah, Hafsa Bibi, Muhammad Usman, Farhan Hameed Khaliq, Usman Ali, Muhammad Imran |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
antihypercholesterolemic
biology Bassiana Pharmacology biology.organism_classification UDP-Glucuronyl transferase system Beauvaria bassiana Structural transformation Article Pharmaceutical Biotechnology Ezetimibe Biochemistry Biotransformation medicine Transferase Cunninghamella blakesleeana biotransformation ezetimibe Biotechnology medicine.drug |
| Zdroj: | Biotechnology, Biotechnological Equipment |
| ISSN: | 1314-3530 1310-2818 |
| DOI: | 10.1080/13102818.2014.966948 |
| Popis: | Structural transformation of ezetimibe was performed by fungi Beauvaria bassiana and Cunninghamella blakesleeana. The metabolites were identified by different spectroscopic techniques as (3R,4S)-1-(4-fluorophenyl)-3-((E)-3-(4-fluorophenyl) allyl)-4-(4-hydroxyphenyl) azetidin-2-one (2), (3R, 4S)-1-(4-fluorophenyl)-3-(3-(4fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl) azetidin-2-one (3), (3R,4S) 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl) propyl)-4-(4-hydroxyphenyl) azetidin-2-one (4) and (2R,5S)-N, 5-bis (4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl) pentanamide (5). This study displays two important features of these fungi, viz., their ability to metabolize halogenated compounds, and their capacity to metabolize drugs that are targets of the UDP-Glucuronyl Transferase System, a phenomenon not commonly observed. |
| Databáze: | OpenAIRE |
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