F806 Suppresses the Invasion and Metastasis of Esophageal Squamous Cell Carcinoma via Downregulating F-Actin Assembly-Related Rho Family Proteins
Autor: | Duo Zheng, Yang-Min Xie, Lei Xie, Li-Yan Xu, Li-Yan Li, Yinwei Cheng, Lian-Di Liao, Li-Hua Tao, Ying-Hua Xie, Xiu-E Xu, En-Min Li |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
rho GTP-Binding Proteins RHOA Article Subject Esophageal Neoplasms Down-Regulation Mice Nude lcsh:Medicine RAC1 Antineoplastic Agents CDC42 General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences Mice 0302 clinical medicine Cell Line Tumor medicine Animals Humans Small GTPase Neoplasm Metastasis Paxillin General Immunology and Microbiology biology Chemistry lcsh:R Cancer General Medicine Actin cytoskeleton medicine.disease Actins Neoplasm Proteins Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis biology.protein Cancer research Esophageal Squamous Cell Carcinoma Research Article |
Zdroj: | BioMed Research International, Vol 2018 (2018) BioMed Research International |
ISSN: | 2314-6141 2314-6133 |
Popis: | Invasion and metastasis are critical pathological and mortal processes in esophageal squamous cell carcinoma (ESCC). Novel drugs, targeting the two cancer migration stages, will augment the treatment options for ESCC therapy and improve overall survival. A novel natural macrolide F806 specifically promotes apoptosis of various ESCC cells. However, whether F806 can inhibit metastasis of ESCC cells needs further evaluation. Here, our data showed that F806 inhibits dynamic F-actin assembly and then suppresses the migration of ESCC cells in vitro and their invasion and metastasis in vivo. The correlation between cancer migration and actin cytoskeleton assembly was consistent with the ability of F806 to prevent the aggregation of Paxillin, an essential protein for focal adhesion formation through binding to the ends of actin filaments. Furthermore, F806 downregulated the expression and activity of the Rho family proteins cell division cycle 42 (CDC42), RAC family small GTPase 1 (RAC1), and RAS homolog family member A (RHOA). Taken together, these results suggest that F806 can suppress cancer invasion and metastasis via interrupting the assembly of migration components involving F-actin. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |