Clinical translation of autologous cell-based tissue engineering techniques as Class III therapeutics in China: Taking cartilage tissue engineering as an example
| Autor: | Wei Zhang, Yangzi Jiang, Boon Chin Heng, Hongwei Ouyang |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Autologous cell Transplantation surgery lcsh:Diseases of the musculoskeletal system Tissue engineering techniques business.industry Process (engineering) Clinical translation Translational medicine Class iii Autologous cells Cartilage tissue engineering Surgery Tissue engineering medicine Orthopedics and Sports Medicine Medical physics lcsh:RC925-935 business |
| Zdroj: | Journal of Orthopaedic Translation, Vol 2, Iss 2, Pp 56-65 (2014) |
| ISSN: | 2214-031X |
| DOI: | 10.1016/j.jot.2014.02.002 |
| Popis: | Summary Autologous cell-based tissue engineering (TE) techniques have been clinically approved for approximately 4 years in China, since the first cartilage TE technique was approved for clinical use by the Zhejiang Health Bureau. TE techniques offer a promising alternative to traditional transplantation surgery, and are different from those for transplanted tissues (biologics or pharmaceutical), the clinical translational procedures are unique and multitasked, and the requirements may differ from those of the target tissues. Thus, the translational procedure is still unfamiliar to most researchers and needs further improvement. This perspectives paper describes the key guidelines and regulations involved in the current translational process, and shares our translational experiences in cartilage TE to provide an example of autologous cell-based TE translation in China. Finally, we discuss the scientific and social challenges and provide some suggestions for future improvements. |
| Databáze: | OpenAIRE |
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